Results 91 to 100 of about 176,999 (285)

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

open access: yesAdvanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin   +18 more
wiley   +1 more source

Time Domain Stress and Fatigue Life Evaluation for the Connector of a Floating Multi-Body in Waves by Total Beam and Local Shell Analyses

open access: yes한국해양공학회지
A floating multi-body with numerous connectors has recently been studied, with the fatigue life evaluation for the connectors a key design step. The total shell analysis for the connectors may be unrealistic.
Byoung Wan Kim   +2 more
doaj   +1 more source

Analysis of methods to increase the efficiency of ship refrigeration plants

open access: yesMATEC Web of Conferences, 2018
The review of the applicable methods for increasing the efficiency of ship refrigeration plants is made. For the presented methods, such as refrigerant subcooling and automatic control of compressors in refrigeration plant, the expediency of application ...
Ovcharenko Igor   +2 more
doaj   +1 more source

Asymmetric Propagation Delay-Aware TDMA MAC Protocol for Mobile Underwater Acoustic Sensor Networks

open access: yesApplied Sciences, 2018
The propagation delay in mobile underwater acoustic sensor network (MUASN) is asymmetric because of its low sound propagation speed, and this asymmetry grows with the increase in packet travel time, which damages the collision avoidance mechanism of the ...
A-Ra Cho   +3 more
doaj   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

open access: yesAdvanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao   +10 more
wiley   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

open access: yesAdvanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran   +10 more
wiley   +1 more source

Study on the Basic Design Method for Deployment of a Deep-Sea Buoyancy Engine Module

open access: yes한국해양공학회지
A deep-sea test module was developed for the operation test of a buoyancy engine at deep-sea, which is one of the key elements of underwater gliders. When a deep-sea module is dropped in water, it is dropped with a weight with greater buoyancy than the ...
Taehwan Joung   +3 more
doaj   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

open access: yesAdvanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang   +8 more
wiley   +1 more source

A Scalable Droplet Microfluidic Platform That Overcomes Large‐Cell Constraints for Long‐Term Plant Cell Culture and Embryogenesis Analysis

open access: yesAdvanced Science, EarlyView.
This work presents a large‐cell‐compatible droplet microfluidic platform that overcomes long‐standing barriers in plant cell culture by enabling high‐fidelity encapsulation, novel multilayer 3D droplet incubation for scalable long‐term culture, and support for the full developmental progression of large plant cells.
Arman Mirmiran   +10 more
wiley   +1 more source

9361: Q-ships

open access: yes
William Butland joined the Navy in 1914 having changed his birthdate by 15 months. He served on HMS Argyll form 16th March 1914 then went to the shore station HMS Vivid from 17th April 1914.
Lest We Forget Project Team (17761757)
core   +1 more source

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