Results 141 to 150 of about 54,957 (265)

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Maritime traffic congestion identification and ship trajectory prediction using temporal graph convolutional networks. [PDF]

PLoS One
Zhou W, Zhang W, Sun S, Zhang Y.
europepmc   +1 more source

Commentary: Additional observations on the skeleton of a juvenile Gryposaurus notabilis (Ornithischia: Hadrosauridae)

The Anatomical Record, EarlyView.
Jordan C. Mallon, David C. Evans, Yuguang Zhang, Hai Xing   +3 more
wiley   +1 more source

Young people's occupational aspirations beyond the aspiration discourse: A sociocultural perspective

British Educational Research Journal, EarlyView.
Abstract Young people's aspirations have been the focus of many educational, sociological and psychological studies. This paper argues, firstly, that the concept of aspirations holds greater generative potential than suggested by the policy‐oriented ‘aspiration discourse’.
Jelena Popov
wiley   +1 more source

The Higher Education Health Insurance Trap: How Underinsurance Fuels Health Inequity and Educational Inaccessibility. [PDF]

J Patient Cent Res Rev
Vanney HE, Satin DJ.
europepmc   +1 more source

How do secondary schools in England talk about modern languages? A corpus‐assisted discourse analysis of school websites

British Educational Research Journal, EarlyView.
Abstract Situating the study within an ecological perspective on language education, this article examines how secondary schools in England present Modern Languages (MLs) on official school websites. Focusing on 44 schools in Local Authorities with the lowest percentage average entry for the Languages pillar of the EBacc, we built a text database ...
Zhu Hua, Yunpeng Du, Elin Arfon
wiley   +1 more source

Tracing the geopolitical influences on the morphological and functional transformation in Guangdong merchant ships: Knowledge mining from the Ming and Qing maritime archives. [PDF]

PLoS One
Ao J, Zhao M, Li W, Feng S, Ye Z, Xu Z, Ji S.   +6 more
europepmc   +1 more source

Magnetoelastic Cell Monitoring System for Evaluating the Effects of Surface Chemistry on the Performance of Mesenchymal Stem Cell Growth

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The recent clinical adoption of cell therapies has increased the need for more efficient, robust, and reproducible manufacturing technologies. Human mesenchymal stromal cells (hMSCs), a major component of the cell and immunotherapeutic market, remain challenging to manufacture at scale because they require surface attachment and are highly ...
William S. Skinner, Carolina Rivera‐Crespo, Eyerusalem A. Gebreyesus, Said Cifuentes, Samantha Tan, Tristen Douglas, Maribella Domenech‐Garcia, Keat Ghee Ong   +7 more
wiley   +1 more source

Hanta on the Hondius - public health and bioethical perspectives of the recent <i>Andes</i> hantavirus cruise ship outbreak. [PDF]

New Microbes New Infect
Tsiodras S, Gkrania-Klotsas E, Mora-Rillo M, Gupta N, Drexler JF, Jokelainen P, Pellejero-Sagastizabal G, Barac A, Paño-Pardo JR, Lescure FX, Grobusch MP.   +10 more
europepmc   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source