Weakly Supervised Learning Significantly Reduces the Number of Labels Required for Intracranial Hemorrhage Detection on Head CT [PDF]
arXiv, 2022 Modern machine learning pipelines, in particular those based on deep learning (DL) models, require large amounts of labeled data. For classification problems, the most common learning paradigm consists of presenting labeled examples during training, thus providing strong supervision on what constitutes positive and negative samples.
arxiv
New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity
ChemMedChem, EarlyView.A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti +13 more
wiley +1 more source
Hemorrhagic Shock and Stress - Cause and Consequence of Hemorheology Disturbances on the Example of the Changes in Erythrocyte Aggregation [PDF]
Journal of Stress Physiology & Biochemistry, 2014 Stress, being the general reaction of the organism to the physical and psychological effects, accompanies all the stages of somatic and psychic formation. Hemorrhagic shock occurring at blood loss appears to be a powerful stress for the organism.
Mantskava M.M. +3 more
doaj
Fed state prior to hemorrhagic shock and polytrauma in a porcine model results in altered liver transcriptomic response. [PDF]
PLoS ONE, 2014 Hemorrhagic shock is a leading cause of trauma-related mortality in both civilian and military settings. Resuscitation often results in reperfusion injury and survivors are susceptible to developing multiple organ failure (MOF).
Charles Determan +6 more
doaj +1 more source
PHE-SICH-CT-IDS: A Benchmark CT Image Dataset for Evaluation Semantic Segmentation, Object Detection and Radiomic Feature Extraction of Perihematomal Edema in Spontaneous Intracerebral Hemorrhage [PDF]
arXiv, 2023 Intracerebral hemorrhage is one of the diseases with the highest mortality and poorest prognosis worldwide. Spontaneous intracerebral hemorrhage (SICH) typically presents acutely, prompt and expedited radiological examination is crucial for diagnosis, localization, and quantification of the hemorrhage.
arxiv
Clinical Pharmacology &Therapeutics, EarlyView.This study aimed to analyze differences in the exposure‐response relationship for factor Xa inhibitors (FXaI) between patients aged ≥ 80 and < 80 years. Patients with atrial fibrillation (AF) taking rivaroxaban, apixaban, or edoxaban were enrolled, and a single steady‐state trough concentration was measured.
Shin‐Yi Lin +7 more
wiley +1 more source
Logistic Regression with Missing Covariates -- Parameter Estimation, Model Selection and Prediction within a Joint-Modeling Framework [PDF]
arXiv, 2018 Logistic regression is a common classification method in supervised learning. Surprisingly, there are very few solutions for performing logistic regression with missing values in the covariates. We suggest a complete approach based on a stochastic approximation version of the EM algorithm to do statistical inference with missing values including the ...
arxiv
Diagnostic Cytopathology, EarlyView.ABSTRACT Myositis ossificans (MO) is a benign soft tissue lesion, characterized by ectopic ossification due to inappropriate fibroblast differentiation, most commonly affecting skeletal muscles. It often occurs in young adults after muscle trauma, predominantly in male patients and very rarely in children. We describe the case of a previously healthy 3‐
Živa Ledinek +7 more
wiley +1 more source
Forecasting heart failure: Seasonal alignment of heart failure outcomes in New York
ESC Heart Failure, Volume 12, Issue 2, Page 819-831, April 2025.Abstract Background Seasonal variations have been observed in heart failure (HF) hospitalization. Numerous explanatory mechanisms have been proposed, but no prior studies have examined potential contributors directly. Our objective was to identify specific factors that could contribute to seasonal variability using a large longitudinal dataset of HF ...
Prerna Gupta +5 more
wiley +1 more source
Profound Thrombocytopenia and Dyspnea 11 Days After Cardiac Surgery
American Journal of Hematology, EarlyView.
Sebastian Vuong +3 more
wiley +1 more source