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Corticosteroids for septic shock
Critical Care Medicine, 2001To gather the data to provide a rationale for using replacement therapy with hydrocortisone in septic shock patients.The Medline and the Cochrane Library databases.Studies in animals and in humans were considered when significant data were available about the mechanisms of action of corticosteroids or about their use in severe sepsis.Corticosteroids ...
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Pathophysiology of Septic Shock
Critical Care Clinics, 2018Fundamental features of septic shock are vasodilation, increased permeability, hypovolemia, and ventricular dysfunction. Vasodilation owing to increased nitric oxide and prostaglandins is treated with vasopressors (norepinephrine first). Increased permeability relates to several pathways (Slit/Robo4, vascular endothelial growth factor, angiopoietin 1 ...
James A, Russell +2 more
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Emergency Medicine Clinics of North America, 2013
Early recognition of sepsis and septic shock in children relies on obtaining an attentive clinical history, accurate vital signs, and a physical examination focused on mental status, work of breathing, and circulatory status. Laboratory tests may support the diagnosis but are not reliable in isolation. The goal of septic shock management is reversal of
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Early recognition of sepsis and septic shock in children relies on obtaining an attentive clinical history, accurate vital signs, and a physical examination focused on mental status, work of breathing, and circulatory status. Laboratory tests may support the diagnosis but are not reliable in isolation. The goal of septic shock management is reversal of
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Annals of Internal Medicine, 1983
Excerpt To the editor: We read with interest the report by Higgins and associates (1) on the reversal of hypotension by continuous infusion of naloxone in a ventilator-dependent patient.
G S, Hughes +3 more
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Excerpt To the editor: We read with interest the report by Higgins and associates (1) on the reversal of hypotension by continuous infusion of naloxone in a ventilator-dependent patient.
G S, Hughes +3 more
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2015
There is still controversy over the use of steroids in the treatment of gram-negative septic shock since there is no evidence of decreased mortality and they may increase gastrointestinal hemorrhage and disseminate the infection. However steroids may prolong life until antibiotic therapy takes effect or surgery is performed and may block toxic effects.
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There is still controversy over the use of steroids in the treatment of gram-negative septic shock since there is no evidence of decreased mortality and they may increase gastrointestinal hemorrhage and disseminate the infection. However steroids may prolong life until antibiotic therapy takes effect or surgery is performed and may block toxic effects.
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JAMA: The Journal of the American Medical Association, 1980
To the Editor.— The article by William Schumer, MD (242:1906, 1979), on the management of septic shock makes several dubious statements and recommendations. The statement, "If... [the septic shock is due to a] pneumonitis, which is caused by Gram-positive bacteria, then a penicillin, a cephalosporin, or an aminoglycoside can be used," is rather ...
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To the Editor.— The article by William Schumer, MD (242:1906, 1979), on the management of septic shock makes several dubious statements and recommendations. The statement, "If... [the septic shock is due to a] pneumonitis, which is caused by Gram-positive bacteria, then a penicillin, a cephalosporin, or an aminoglycoside can be used," is rather ...
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Septic Shock and Corticosteroids
New England Journal of Medicine, 1981The use of a massive dose of a glucocorticoid in the patient with septic shock remains controversial.
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