Results 271 to 280 of about 962,165 (321)

The Association Between Time to Completion of at Least 30 mL/kg and Hospital Outcomes Among Patients With Septic Shock. [PDF]

Crit Care Explor
Piehl M, Adejumo FF, Maio V.
europepmc   +1 more source

Ultralow‐Dimensionality Reduction for Identifying Critical Transitions by Spatial‐Temporal PCA

Advanced Science, EarlyView.
The proposed spatial‐temporal principal component analysis (stPCA) method analytically reduces high‐dimensional time‐series data to a single latent variable by transforming spatial information into temporal dynamics. By preserving the temporal properties of the original data, stPCA effectively identifies critical transitions and tipping points.
Pei Chen, Yaofang Suo, Kazuyuki Aihara, Ye Li, Dan Wu, Rui Liu, Luonan Chen   +6 more
wiley   +1 more source

Gender differences in co-rumination and transition shock among nursing interns in China: a cross-sectional study. [PDF]

BMC Nurs
Ge WJ, Zhu SJ, Zhu XY, Chu AQ.
europepmc   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Prognostic value of lactate clearance, fluid balance, and APACHE II score in patients with cardiogenic shock receiving extracorporeal membrane oxygenation. [PDF]

Front Cardiovasc Med
Zhang QF, Zhang SL, Li G, Guo M, Qi XX, Xing XH, Wang Z.   +6 more
europepmc   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Therapeutic Potential of Centhaquine Citrate, a Selective Alpha-2B Adrenoceptor Agonist, in the Management of Circulatory Shock. [PDF]

Drugs
Legrand M, Ranjan A, Rammohan S, De Backer D, Ostermann M, Gulati A, Vincent JL, Khanna AK.   +7 more
europepmc   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

A Heat-Shock Transcription Factor in <i>Panax ginseng</i>, <i>PgHSFA2</i>, Confers Heat and Salt Resistance in Transgenic Tobacco. [PDF]

Int J Mol Sci
Jeon SW, Kim YR, Han JY, Jeong U, Cheong EJ, Choi YE.   +5 more
europepmc   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source