Results 171 to 180 of about 98,186 (302)

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Predictors of device-related adverse events in patients with intra-aortic ballon pump or microaxial flow pump for cardiogenic shock. [PDF]

JHLT Open
Provenzano Z, Patel Z, Jnawali C, Mittelstaedt R, Ospina M, Samani S, Peller J, Marchell C, Ohlrich K, Gunn B, Varrone M, Dodson K, Bull L, Hajj J, Gregoski MJ, Tedford RJ, Blanding W, McMurray J, Witer L, Kilic A, Houston BA, Carnicelli AP.   +21 more
europepmc   +1 more source

Validity of the elastase assay in intensive care medicine [PDF]

, 1988
Fritz, Hans, Jochum, Marianne, Lang, H., Redl, H., Redl, H., Schlag, G.   +5 more
core  

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Describing hemodynamic states: a plea for systematic terminology. [PDF]

J Clin Monit Comput
Saugel B, Lakhal K.
europepmc   +1 more source

Resuscitation of patients with septic shock: please "mind the gap"! [PDF]

, 2013
Cecconi, M, Pinsky, MR, Vallet, B
core   +1 more source

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

Mechanical Circulatory Support in the Very Elderly Undergoing Complex High-Risk Indicated Procedures: A Case Report and Literature Review. [PDF]

J Cardiovasc Dev Dis
Giacchi G, Nicosia A.
europepmc   +1 more source

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source

Global research trends and hotspots in extracorporeal membrane oxygenation for cardiogenic shock: a bibliometric review and knowledge mapping approach (1990-2024). [PDF]

J Thorac Dis
Chen S, Guo W, Liu L, Hu D, Zhu Y, Xue H, Yuan S, Zhu N, Li H, Liu A, Yang Y, Qiu H, Liu S.   +12 more
europepmc   +1 more source