Results 231 to 240 of about 472,206 (302)

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Immediate-early genes Arc and c-Fos show divergent brain-wide expression following contextual fear conditioning. [PDF]

Commun Biol
Bulthuis NE, Quintana LI, Stackmann M, Denny CA.   +3 more
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

The Role of Innate Lymphoid Cells in the Pathogenesis of Hepatic Echinococcosis: A Literature Review. [PDF]

Parasite Immunol
Ma W, Wang D, Liu C, Fan H.
europepmc   +1 more source

Peak Lactate Within 24 h and Mortality in Septic Shock Patients Receiving Continuous Renal Replacement Therapy: A Real-World Cohort from an Asian ICU (2018-2020). [PDF]

Life (Basel)
Chang WH, Hu TY, Kuo LK.
europepmc   +1 more source

Role of HDAC6 in carcinomas. [PDF]

Discov Oncol
Chen P, Zhang YL.
europepmc   +1 more source

Time Course of Neural Process of Certain and Uncertain Punishment in Decision Making. [PDF]

Behav Sci (Basel)
Qiu W, Fu H, Zhang L, Ma Q, Cheng L.
europepmc   +1 more source

The relationship between transition shock and person-organization fit among newly graduated registered nurses in China: the mediating role of resilience. [PDF]

BMC Nurs
Feng L, Zeng Y, Chen X, Zhang Y, Zhang J.   +4 more
europepmc   +1 more source

Dynamic damage and crack propagation of granite under thermal shock: DEM modeling insights. [PDF]

Sci Rep
Su L, Li H, Chi Q, Yang X, Gao X, Huang X.   +5 more
europepmc   +1 more source