Results 41 to 50 of about 471,315 (302)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]

, 1994
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
Craig, Elisabeth A., Herrmann, Johannes M., Neupert, Walter, Stuart, Rosemary A.   +3 more
core   +4 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Formation of surface defects by thermal shock method for the improved photocatalytic activity of ZnO nanoparticles

Journal of Asian Ceramic Societies, 2020
Surface-modified ZnO photocatalysts with enhanced UVA-light-driven and visible-light-driven activities were synthesized by the thermal shock method with Cu(NO3)2 at different thermal shock temperatures (300 – 600°C).
Tien Khoa Le, The Luan Nguyen, Chau Ngoc Hoang, Dieu Khanh An Nguyen, Torben Lund, Huu Khanh Hung Nguyen, Thi Kieu Xuan Huynh   +6 more
doaj   +1 more source

Numerical Investigation on Aerodynamic Performances of the Single-Stage Transonic Turbine With Various Coolant Ejection Positions and Coolant Mass Flow Rates

Frontiers in Energy Research, 2022
The effects of film cooling holes on the suction surface and the coolant mass flow were studied in this research, which focused on load distribution and flow characteristics such as shock migration.
Jinming Zhang, Xun Zhou, Wei Du, Senpei Xu   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Enhancing shock wave energy dissipation in metallosupramolecular polymer by tuning metal-imidazole coordination interactions

Polymer Testing
The development of materials capable of shock wave energy dissipation (SWED) is critical for modern protective applications. In this study, metallosupramolecular poly(dimethylsiloxane) (PDMS) networks cross-linked with Zn2+, Cu2+, and Ni2+ ions and ...
Seungrae Cho, Hyemi Lee, Sieun Je, Juho Lee, Suwon Bae, Tae Ann Kim, Jaejun Lee   +6 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Experimental Study of the Load-Transfer Law and Shock Environment of a Pipe–Float System

Journal of Marine Science and Engineering
To study the load-transfer law and shock environment of a pipe–float system, an experimental model was designed, manufactured, and installed on a floating shock platform.
Miaoran Li, Jun Li, Wei Chen, Zhiyang Lei, Lijiang Zhou, Mengzhen Li, Chun Bao Li, Xiaobin Li   +7 more
doaj   +1 more source

Effect of Repeated Thermal Shock on Mechanical Properties of ZrB2-SiC-BN Ceramic Composites

The Scientific World Journal, 2014
ZrB2-20 vol.% SiC-10 vol.% h-BN (particles) ceramic composites (ZSB) were fabricated by hot pressing under inert gas protected. ZSB samples with mean size 75 × 55 × 40 mm3 were heated using current heating method and then cooled down to low temperature ...
Gang Li, Hongbo Chen
doaj   +1 more source