TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain
Advanced Science, EarlyView.TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando +2 more
wiley +1 more source
Circulating granzyme A is elevated within the dysregulated host response and associates with mortality in abdominal sepsis. [PDF]
Front ImmunolPellejero-Sagastizabal G +10 more
europepmc +1 more source
Advanced Science, EarlyView.Rod Origami (RodOri) springs harness snap‐through instabilities of pre‐stressed curved rods with geometrically programmable buckling behavior. Integrating RodOri springs with distinct geometries yields multistable metamaterials that undergo stepwise reconfiguration via sequential snapping, achieving wide‐range tunability of stiffness and resonance ...
Jeseung Lee +2 more
wiley +1 more source
Elderly patients with healthcare-associated infections in the emergency department: clinical characteristics and risk factors for septic shock: a retrospective study. [PDF]
BMC GeriatrÇelik FH +7 more
europepmc +1 more source
Uncertainty‐Aware Deep Ensembles for Robust and Reliable Chemical Sensor Arrays
Advanced Science, EarlyView.A reliability‐aware electronic nose is developed using photothermally anchored metal‐catalyst decorated metal oxide nanofiber sensor arrays combined with deep ensemble learning. Diverse catalytic nanofiber channels generate gas‐specific response patterns, enabling selective identification and quantification of sulfur‐containing gases.
Sungwoo Eo +5 more
wiley +1 more source
From microscopy to antimicrobial decisions: a clinically grounded roadmap for critical care infectious diseases. [PDF]
Front Artif IntellQu HL +5 more
europepmc +1 more source
Advanced Science, EarlyView.This review examines perovskite‐based X‐ray detectors from a materials‐to‐medical‐images perspective. Recent progress in perovskite‐based X‐ray detectors is discussed with emphasis on their relevance to clinical imaging. The key barriers to clinical implementation are analyzed.
Sibin Wang +8 more
wiley +1 more source
Cardiorenal Hemodynamic Coupling: Mechanical Circulatory Support Augments Renal Blood Flow via Renal Vasodilation. [PDF]
JACC Basic Transl SciZale RE, Edelman ER.
europepmc +1 more source
Non‐Equilibrium Synthesis of Whitlockite Assisted by Localized H2O Vapor Pressure
Advanced Science, EarlyView.A carbon substrate acts as a microheater during intense pulsed light irradiation, enabling rapid heating and cooling for whitlockite formation. In contrast to conventional white ceramic synthesis with weak photothermal response, this platform concentrates thermal energy locally and promotes phase‐selective crystallization under ultrafast ...
Min‐Jung Kim +5 more
wiley +1 more source
Early biomarkers for predicting sepsis-induced shock: insights from inflammatory pathways and immune response. [PDF]
Front PharmacolLi J +5 more
europepmc +1 more source