Results 41 to 50 of about 495,808 (350)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Determination of the adaptive and productive clones of poplar at four-year short-rotation system [PDF]

open access: yesتحقیقات جنگل و صنوبر ایران, 2006
Poplar as fast growing tree with a great potential of coppicing at consecutive periods is the most suitable tree species to provide wood at short period. The high volume of wood at short periods (2-5years) produced under the short rotation system is used
Ali Reza Modir-Rahmati, Reza Baghery
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Root hairs matter at field scale for maize shoot growth and nutrient uptake, but root trait plasticity is primarily triggered by texture and drought [PDF]

open access: hybrid, 2022
Doris Vetterlein   +16 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Functional Links between Biomass Production and Decomposition of Vetiver (Chrysopogon zizanioides) Grass in Three Australian Soils

open access: yesPlants, 2022
Plant roots are primary factors to contribute to surface and deep soil carbon sequestration (SCS). Perennial grasses like vetiver produce large and deep root system and are likely to contribute significantly to soil carbon.
Bezaye Tessema   +4 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

BIOLOGICAL FEATURES AND SOWING QUALITIES OF NON-CLOTTING GARLIC, DEPENDING ON THE LOCATION OF THE GARLIC CLOVES IN THE BULB

open access: yesОвощи России, 2018
Research conducted at the Institute of Genetics, Physiology and Plant Protection found that when using the peripheral and internal cloves of garlic for planting in comparison with the use of them of different locations without calibrating them by mass ...
A. I. Кilinchuk, V. F. Botnari
doaj   +1 more source

Injury Characteristics, Outcomes, and Health Care Services Use Associated With Nonfatal Injuries Sustained in Mass Shootings in the US, 2012-2019 [PDF]

open access: gold, 2022
Matthew P. Czaja   +25 more
openalex   +1 more source

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