Results 71 to 80 of about 3,183,655 (317)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Short- and long-term memory: differential involvement of neurotransmitter systems and signal transduction cascades

Anais da Academia Brasileira de Ciências, 2000
Since William James (1890) first distinguished primary from secondary memory, equivalent to short- and long-term memory, respectively, it has been assumed that short-term memory processes are in charge of cognition while long-term memory is being ...
MÔNICA R.M. VIANNA, LUCIANA A. IZQUIERDO, DANIELA M. BARROS, ROGER WALZ, JORGE H. MEDINA, IVÁN IZQUIERDO   +5 more
doaj   +1 more source

Deep long short-term memory networks for nonlinear structural seismic response prediction

Computers & structures, 2019
This paper presents a comprehensive study on developing advanced deep learning approaches for nonlinear structural response modeling and prediction. Two schemes of the long short-term memory (LSTM) network are proposed for data-driven structural seismic ...
Ruiyang Zhang, Zhao Chen, Su Chen, Jingwei Zheng, O. Buyukozturk, Hao Sun   +5 more
semanticscholar   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Streamflow and rainfall forecasting by two long short-term memory-based models

, 2020
Prediction of streamflow and rainfall is important for water resources planning and management. In this study, we developed two hybrid models, based on long short-term memory network (LSTM), for monthly streamflow and rainfall forecasting.
Lingling Ni, Dong Wang, V. Singh, Jianfeng Wu, Yuankun Wang, Yuwei Tao, Jianyun Zhang   +6 more
semanticscholar   +1 more source

Short-term memory and long-term memory are still different. [PDF]

, 2017
A commonly expressed view is that short-term memory (STM) is nothing more than activated long-term memory. If true, this would overturn a central tenet of cognitive psychology-the idea that there are functionally and neurobiologically distinct short- and
Norris, Dennis
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

The Short Term Memory Structure In State-Of-The Art Recall/Recognition Experiments of Rubin, Hinton and Wentzel [PDF]

, 2005
Properties of a short term memory structure are discovered in the data of Rubin, Hinton and Wenzel (1999): Recall (recognition) probabilities and search times are linearly related through stimulus presentation lags from 6 seconds to 600 (350) seconds ...
Tarnow, Dr. Eugen
core  

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source