Results 51 to 60 of about 2,448 (302)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Game Changer to Short‐Term Rentals in Spain

International Journal of Tourism Research
ABSTRACTUsually, when it comes to short‐term rentals (STRs), there are three approaches: prohibition, limitation or laissez‐faire. Using experimental data on STRs from the National Statistics Institute, we analyse the fluctuations in their figures in all municipalities in Spain to determine whether there is a link between the type of regulation and its
Francisco Sánchez‐Cubo, Alba Viana‐Lora   +1 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Shared Economy in the Czech Republic in 2017 and Resulting Problems in Short-Term Housing Rentals [PDF]

ACTA VŠFS, 2017
In the article we present a pilot study about most prominent problem of the shared economy – the increase in short-term housing rentals (through the Airbnb platform) and its impact on original accommodation services.
Petr Makovský
doaj  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

When tourism meets law:governing short-term rentals in Slovenia

Mednarodno Inovativno Poslovanje
Purpose of the article – is to provide insight into regulatory efforts concerning short-term rentals (STRs) of private accommodations for tourists in Slovenia. The study examines the perspectives of public sector representatives engaged in STR regulation
Saša Zupan Korže, Saška Štajnmec
doaj   +1 more source

Home Dispossession and Commercial Real Estate Dispossession in Tourist Conurbations. Analyzing the Reconfiguration of Displacement Dynamics in Los Cristianos/Las Américas (Tenerife)

Urban Science, 2021
Since the onset of the global financial crisis, urban dwellers face an increasing number of obstacles in establishing themselves on the housing market.
Dennis Hof
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

“Airbnb in the City”: assessing short-term rental regulation in Bordeaux

The Annals of Regional Science, 2023
Short-term rental platforms, led by Airbnb, have disrupted the tourism accommodation industry over the last decade. This disruption has encouraged policy-makers to intervene. However, little is known about how effective such interventions are. This paper empirically evaluates the impact Bordeaux's regulation has had on short-term rental (STR) activity ...
Calum Robertson, Sylvain Dejean, Raphaël Suire   +2 more
openaire   +3 more sources