Results 191 to 200 of about 11,314,625 (239)

Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17. [PDF]

Protein Sci
Tagawa J, Yanaka S, Kato Y, Masuda A, Lee JM, Senoo A, Oyama K, Uchihashi T, Nishida M, Kusakabe T, Caaveiro JMM.   +10 more
europepmc   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

RNA Isolation from Mouse Ocular Lens Epithelium and Fiber Cell Bulk Masses. [PDF]

J Vis Exp
Huynh PN, Vu MP, Cheng C.
europepmc   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Investigations into multiple fission yeast chromosome size determinants. [PDF]

J Cell Sci
Wu PS, Fallesen T, Uhlmann F.
europepmc   +1 more source

Adaptive intrathecal nanorobotics in mice and nonhuman primates for navigated CNS therapy. [PDF]

Sci Adv
Lu Y, Fan X, Fan C, Zhang G, Cui H, Jiang Y, Zhang S, Jia Y, Dong R, Tan H, Zhang L, Wu Z.   +11 more
europepmc   +1 more source

Experimental Study on Anxiolytic and Antidepressant Effects of Zhi-Chi-Jie-Yu Granules in CUMS Mice and Prediction of Underlying Molecular Mechanisms. [PDF]

Neuropsychiatr Dis Treat
Luo Y, Gao X, Shi W, Cheng X, Zhou Y, Wang R, Chen Y.   +6 more
europepmc   +1 more source

PGK1 Drives Glial Glycolytic Reprogramming to Mediate Isoflurane-Induced Cognitive Impairment in Aged Mice. [PDF]

J Cell Mol Med
Ren Z, Hu H, Guo J, Liu Y, Qiu C, Yuan K, Ma Y, Jiao S, Guo R, Zhao D, Zhang D, Zeng Y, Ma J, He M.   +13 more
europepmc   +1 more source

Human Milk Oligosaccharide LNnT Attenuates Colonic Barrier Dysfunction and Associated Cognitive Impairment via Modulating Sphingolipid Metabolism and Gut Microbiota. [PDF]

Molecules
Wang M, Zhu L, Liao J, Bao L, Li H, Deng Z, Li J, Zheng L, Zhang B.   +8 more
europepmc   +1 more source

A combined individualized cycling exercise and artificial gravity training protocol as a spaceflight deconditioning countermeasure. [PDF]

NPJ Microgravity
Ap B, Dn D, Stead T, Taylor C, Xu D, Van Ombergen A, Goswami N.   +6 more
europepmc   +1 more source