Results 141 to 150 of about 5,061,137 (286)
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
Advanced Science, EarlyView.A dual‐randomness hardware platform is demonstrated by integrating PUF and TRNG functionalities into mixed‐ZGO nanoclusters. By leveraging spatial and temporal stochasticity, the mixed‐ZGO NCs device enables both unique identification and random signal generation.
Seungme Kang +6 more
wiley +1 more source
Advanced Science, EarlyView.A self‐sustainable vehicular vibration and indoor environment monitoring IoT platform is developed which integrates a hybrid spring‐coupled broadband energy harvester with a machine learning‐assisted PAN‐CuSCN nanofiber triboelectric vibration sensor for subtle‐to‐wide‐range vibration detection and road/speed classification.
Trilochan Bhatta +6 more
wiley +1 more source
Advanced Science, EarlyView.A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan +5 more
wiley +1 more source
Advanced Science, EarlyView.A pork belly‐inspired all‐biomass composite film was constructed through layer‐by‐layer assembly of cellulose nanofibers (CNFs), gelatin, and graphitized carbon nanosheets (GCNs) via hydrogen bonding and π–π stacking interactions. The excellent mechanical properties, effective thermal management, and outstanding EMI shielding performance of the ...
Junchao Ren +12 more
wiley +1 more source
On-farm practices like premature weaning and frequent regrouping induce stress to pigs. Early socialization or environmental enrichment in piglets reduce weaning stress, as suggested in previous studies. Little research with both effects and in commercial settings was found.
Ko, Heng-Lun|| +5 more
openaire +1 more source
Metasurface‐Based Multidimensional Light‐Field Manipulation: From Technologies to Applications
Advanced Science, EarlyView.Multidimensional metasurfaces enable versatile manipulation of multiple optical degrees of freedom, including phase, amplitude, polarization, wavelength, and orbital angular momentum. This review summarizes their fundamental mechanisms, emerging strategies for multidimensional light‐field control, and key applications in optical computing, imaging ...
Heliang Yin +6 more
wiley +1 more source
In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma
Advanced Science, EarlyView.By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He +20 more
wiley +1 more source
Advanced Science, EarlyView.This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu +15 more
wiley +1 more source