Results 61 to 70 of about 600,345 (283)

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis [PDF]

, 2015
Truncating mutations in the tumor suppressor gene adenomatous polyposis coli (APC) are the initiating step in the vast majority of sporadic colorectal cancers, and they underlie familial adenomatous polyposis (FAP) syndromes.
Creytens, David, Geurs, Sarah, Naert, Thomas, Sanders, Ellen, Tran Thi, Hong, Van Imschoot, Griet, Van Nieuwenhuysen, Tom, Van Roy, Frans, Vleminckx, Kris   +8 more
core   +3 more sources

Spaced seeds improve k-mer-based metagenomic classification [PDF]

, 2015
Metagenomics is a powerful approach to study genetic content of environmental samples that has been strongly promoted by NGS technologies. To cope with massive data involved in modern metagenomic projects, recent tools [4, 39] rely on the analysis of k ...
Brinda, Karel, Kucherov, Gregory, Sykulski, Maciej   +2 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Complete chloroplast genome and phylogenetic analysis of Iris confusa (Iridaceae)

Mitochondrial DNA. Part B. Resources
Iris confusa Sealy is highly valued for its ornamental and medicinal applications. Here, we report the complete chloroplast genome sequence of I. confusa obtained using Illumina pair-end sequencing. The complete circular genome of I.
Ya-nan Li, Jing Yan, Yan-xia Zheng
doaj   +1 more source

Five-year microevolution of a multidrug-resistant Mycobacterium tuberculosis strain within a patient with inadequate compliance to treatment

BMC Infectious Diseases, 2021
Background Whole-genome sequencing has shown that the Mycobacterium tuberculosis infection process can be more heterogeneous than previously thought.
Darío A. Fernandez Do Porto, Johana Monteserin, Josefina Campos, Ezequiel J. Sosa, Mario Matteo, Federico Serral, Noemí Yokobori, Andrés Fernández Benevento, Tomás Poklepovich, Agustín Pardo, Ingrid Wainmayer, Norberto Simboli, Florencia Castello, Roxana Paul, Marcelo Martí, Beatriz López, Adrián Turjanski, Viviana Ritacco   +17 more
doaj   +1 more source

Genome sequence of canine herpesvirus [PDF]

, 2016
Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United ...
Davison, Andrew, Graham, Elizabeth M., McDonald, Michael, Papageorgiou, Konstantinos V., Suárez, Nicolás M., Wilkie, Gavin S.   +5 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Detecting epistasis via Markov bases [PDF]

, 2010
Rapid research progress in genotyping techniques have allowed large genome-wide association studies. Existing methods often focus on determining associations between single loci and a specific phenotype.
Malaspinas, Anna-Sapfo, Uhler, Caroline
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

RNA from a simple-tandem repeat is required for sperm maturation and male fertility in Drosophila melanogaster. [PDF]

, 2019
Tandemly-repeated DNAs, or satellites, are enriched in heterochromatic regions of eukaryotic genomes and contribute to nuclear structure and function. Some satellites are transcribed, but we lack direct evidence that specific satellite RNAs are required ...
Allshire, Brown, Cai, Chen, Demarco, Dernburg, Ding, Eren-Ghiani, Ferree, Herbert, Hoskins, Hoskins, Jagannathan, Jain, Jandura, Jayaramaiah Raja, Johnson, Kaessmann, Kelemen, Kost, Larracuente, Legendre, Lohe, Lohe, McKee, McNulty, Ni, Nicholson, Pathak, Rathke, Rathke, Rinn, Rošić, Shirai, Shpiz, Steinhauer, Strom, Sun, Velazquez Camacho, Wei, White-Cooper, White-Cooper, Yap, Yuan, Zhu   +44 more
core   +2 more sources