Results 81 to 90 of about 1,098,731 (281)

Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression. [PDF]

, 2015
The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons of the lateral sector of the posterior hypothalamus and zona incerta.
Benedetto, Luciana, Chase, Michael H, Lagos, Patricia, López-Hill, Ximena, Monti, Jaime M, Pascovich, Claudia, Scorza, Cecilia, Torterolo, Pablo, Urbanavicius, Jessika   +8 more
core   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

What can a mean-field model tell us about the dynamics of the cortex? [PDF]

, 2010
In this chapter we examine the dynamical behavior of a spatially homogeneous two-dimensional model of the cortex that incorporates membrane potential, synaptic flux rates and long- and short-range synaptic input, in two spatial dimensions, using ...
Gillies, Iain-Patrick, Hailstone, David J., Sleigh, James W., Steyn-Ross, D. Alistair, Steyn-Ross, Moira L., Wilson, Marcus T.   +5 more
core   +2 more sources

Correlates of short sleep duration among adolescents

Journal of Adolescence, 2019
ABSTRACTIntroductionShort sleep duration is exceedingly common among adolescents and has implications for healthy youth development. We sought to document associations between adolescents’ sleep duration and characteristics of their schedules, behaviors, and wellbeing.MethodsWe used data from the baseline wave (9th grade year) of the START study, a ...
Rachel, Widome, Aaron T, Berger, Kathleen M, Lenk, Darin J, Erickson, Melissa N, Laska, Conrad, Iber, Gudrun, Kilian, Kyla, Wahlstrom   +7 more
openaire   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A three-phase epidemiological study of short and long sleepers in a middle-aged Chinese population: prevalence and characteristics

Brazilian Journal of Medical and Biological Research, 2014
Epidemiological studies of short and long sleepers have not been conducted previously. We collected socioeconomic, psychological, and polysomnographic characteristics of 6501 parents (3252 men and 3249 women) of 4036 primary school children in Guangzhou ...
Y.L. Hao, B. Zhang, F.J. Jia, X.L. Li, Y. Tang, Y.Z. Ren, W.H. Liu   +6 more
doaj   +1 more source

Impact of Short Sleep Duration on the Incidence of Obesity and Overweight among Children and Adolescents

Medicina, 2022
Background and Objectives: The prevalence of obesity among children is increasing and is highlighting many problems. Lack of sleep is common among children and adolescents.
Seung-Ho Han, Jae-Yong Yee, Jung-Soo Pyo
doaj   +1 more source

Overnight consolidation aids the transfer of statistical knowledge from the medial temporal lobe to the striatum [PDF]

, 2012
Sleep is important for abstraction of the underlying principles (or gist) which bind together conceptually related stimuli, but little is known about the neural correlates of this process.
Albouy, Backhaus, Benedict, Born, Brown, Brown, Cartwright, Dang-Vu, Darsaud, Debarnot, Diekelmann, Dijk, Djonlagic, Dumay, Durrant, Durrant, Durrant, Eichenbaum, Eichenbaum, Ellenbogen, Fischer, Fischer, Frankland, Friston, Furl, Gais, Gais, Gais, Gais, Gais, Glenville, Gomez, Herdener, Hu, Kim, Kumaran, Kumaran, Kumaran, Kuriyama, Lau, Lewis, Maldjian, Massimini, McClelland, Mograss, Munoz-Lopez, Nadel, Overath, Overath, Peigneux, Pelucchi, Penelope A. Lewis, Perruchet, Poldrack, Poldrack, Poldrack, Poldrack, Press, Rasch, Rechtschaffen, Reiss, Remillard, Rieckmann, Robertson, Robertson, Rostami, Saffran, Saffran, Saffran, Saletin, Scott A. Cairney, Siegel, Simon J. Durrant, Sterpenich, Stickgold, Takashima, Takashima, Tamminen, Tononi, Tononi, Tse, Turk-Browne, Turk-Browne, Tzourio-Mazoyer, Valentin, Van Dongen, van Kesteren, Wagner, Walker, Walker, Walker, Walker, Wilhelm, Worsley, Yang, Yordanova, Yordanova   +96 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Short sleep duration, complaints of vital exhaustion and perceived stress are prevalent among pregnant women with mood and anxiety disorders [PDF]

, 2012
Background: Psychiatric disorders have been associated with sleep disorders in men and non-pregnant women, but little is known about sleep complaints and disorders among pregnant women with psychiatric disorders.
Fida, Neway, Gelaye, Bizu, Qiu, Chunfang, Williams, Michelle A   +3 more
core   +2 more sources