Results 121 to 130 of about 3,413,614 (250)

MEK Inhibitor Associated Airway Injury in an Infant With Noonan Syndrome: A Case Report

The Laryngoscope, EarlyView.
An infant with Noonan syndrome treated with trametinib developed extensive mucosal sloughing of the upper and lower airway, followed by severe supraglottic scarring. Clinicians should consider airway toxicity as a potential adverse effect of MEK inhibitor therapy.
Veronica Drozdowski‐Nuccio, Rachel D. Yoon, Steven Tomasi, Dana M. Thompson, Inbal Hazkani   +4 more
wiley   +1 more source

Impact of Age and Nerve Impairment Interaction on Bell's Palsy Prognosis

The Laryngoscope, EarlyView.
This study investigated the prognostic impact of the interaction between aging and nerve impairment severity in 181 patients with Bell's palsy. Although age alone was not an independent predictor, the interaction between older age (≥ 65 years) and a Nerve Excitability Test threshold difference (≥ 3.5 mA) significantly increased the risk of incomplete ...
Hiroyuki Yamada, Miyuki Oshita, Takemichi Tanaka, Shota Miyaji, Takuya Kimura, Shinji Iwata, Ryota Takagi, Naohito Hato   +7 more
wiley   +1 more source

Species‐Specific Shrub Encroachment Drives Divergent Soil Fungal Assembly Processes and Network Structures in Alpine Meadows

Land Degradation &Development, EarlyView.
ABSTRACT Shrub encroachment is rapidly transforming alpine meadow ecosystems worldwide, yet its consequences for belowground microbial organization remain insufficiently understood, particularly when different shrub species exert contrasting ecological effects.
Yang Liu, Hong Xiao, Yuping Rong, Kuiju Niu, Kai Ma, Yun Wang, Xin Zhang, Linqian Song   +7 more
wiley   +1 more source

Etiology of Short Stature in Northern India

Journal of the ASEAN Federation of Endocrine Societies, 2016
Objective. Short stature can be caused by a great variety of congenital and acquired conditions, some of which present with additional symptoms and signs.
Manish Gutch, Kumar Sukriti, Gupta Kumar Keshav, Mohd Razi Syed, Gupta Abhinav, Bhattacharjee Annesh, Ravi Mishra   +6 more
doaj  

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

Root biomass distribution in response to increasing active layer thickness across plant communities in a permafrost peatland

Nordic Journal of Botany, EarlyView.
In Arctic tundra, the majority of plant biomass is belowground. As temperatures increase and permafrost thaws, new soil volume containing nitrogen becomes available for plant roots, potentially leading to new plant–soil interactions. Whether or not different plant communities adapt their rooting depth distribution in response to increasing active layer
Alexandra Werner, Lena Muffler, Gesche Blume‐Werry   +2 more
wiley   +1 more source

Short stature, primary care approach and diagnosis

, 2016
The following review article main objective seeks to provide an approach from a health care first level institution, of one of the mostfrequent queries in pediatrics and general medicine, stunted growth.
Gómez Tarazona, Carlos A., Mendoza Rojas, Víctor Clemente   +1 more
core  

The Audiologic and Otolaryngologic Phenotype in WHIM Syndrome

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis syndrome) is an ultra‐rare primary immunodeficiency disease caused by autosomal dominant hyperfunctional mutations in the chemokine receptor CXCR4. Otolaryngologists are frequently consulted to evaluate WHIM patients because of recurrent acute ear and sinus ...
Christopher K. Zalewski, H. Jeffrey Kim, Carmen C. Brewer, Sophia Martinez, Caroline Rieger, Elena Cho, David H. McDermott, Philip M. Murphy   +7 more
wiley   +1 more source

Long-term vosoritide treatment sustains bone growth and may enhance wellbeing in children with achondroplasia: a plain language summary

Future Rare Diseases
Florian Innig, Victoria Garcia, Marco Sessa, Marco Stadler, Julie Hoover-Fong   +4 more
doaj   +1 more source

Mechanisms and impacts of future plant invasions: research agendas and management needs under disruptive social‐ecological change scenarios

Oikos, EarlyView.
No‐analogue futures are characteristic of the Anthropocene, but how global change, and societies' responses, will affect plant invasions remains unclear. Conducting research now to address future needs is crucial for guiding invasion management and policy.
Jennifer L. Bufford, Angela J. Brandt, Rowan Sprague, Christopher E. Buddenhagen, Richard P. Duncan, Nichola Harcourt, Philip E. Hulme, Hao Ran Lai, Kate G. McAlpine, Chris McGrannachan, Fiona J. Thomson, Vincent van Uitregt, Duane A. Peltzer   +12 more
wiley   +1 more source