Results 51 to 60 of about 1,077,102 (296)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Context of the inventory management expenses in the case of planned shortages

open access: yesEngineering Management in Production and Services, 2017
The main purpose of the paper is to present the relations between the different cost factors of the inventory management systems, and the context between the order quantities and the cost level.
Korponai János   +2 more
doaj   +1 more source

Production inventory model with disruption considering shortage and time proportional demand [PDF]

open access: yesYugoslav Journal of Operations Research, 2018
The disruption in a production system occurs due to labor problem, machines breakdown, strikes, political issue, and weather disturbance, etc. This leads to delay in the supply of the products, resulting customer to approach other dealers for the ...
Khedlekar U.K., Namdeo A., Nigwal A.
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

El desabastecimiento de géneros agrícolas en la Provincia de Cartagena de Indias a fines del período colonial

open access: yesHistoria Crítica, 2013
This article analyzes the problem of food shortages in Cartagena de Indias in the second half of the eighteenth century and first decade of the nineteenth century. It examines the soil conditions in the province, its water resources, and diverse types of
Alexander O'Byrne H.
doaj   +1 more source

A periodic review inventory model with stock dependent demand, permissible delay in payment and price discount on backorders [PDF]

open access: yesYugoslav Journal of Operations Research, 2014
In this paper we study a periodic review inventory model with stock dependent demand. When stock on hand is zero, the inventory manager offers a price discount to customers who are willing to backorder their demand. Permissible delay in payments
Pal Manisha, Chandra Sujan
doaj   +1 more source

The hard X-ray behavior of Aql X-1 during type-I bursts

open access: yes, 2013
We report the discovery of an anti-correlation between the soft and the hard X-ray lightcurves of the X-ray binary Aql X-1 when bursting. This behavior may indicate that the corona is cooled by the soft X-ray shower fed by the type-I X-ray bursts, and ...
Chen, Yu-Peng   +7 more
core   +1 more source

Recruiting doctors from poor countries: the great brain robbery? [PDF]

open access: yes, 2003
An important impediment to achieving health for all in developing countries is the shortage of doctors and nurses.
Patel, Vikram
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

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