Results 81 to 90 of about 47,764 (259)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
On finding shortest paths in nonnegative networks
Discrete Mathematics, 1974 AbstractA modification of Dantzig's algorithm for the all pairs shortest paths problem is given. The new algorithm applies only to graphs with nonnegative arc lengths. For an N-node complete graph it has a worst case running time of 23N3 triple operations of the form Dij: = min(Dij, Dik + Dkj) and N2 log N other comparisons. This contrasts with a lower
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The Algorithm for Solving Shortest-Path Problems Based on Electrical Circuit Laws [PDF]
Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2011 Shortest-path problem is one of the well-known optimization problems that has been studied by many scientists in recent years. Applications of this problem such as transportation and communication are generally solved by Dijkstra's Algorithm (Labeling ...
Ali Khatami Firoozabadi +2 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
A Novel Index Method for K Nearest Object Query over Time-Dependent Road Networks
Complexity, 2019 K nearest neighbor (kNN) search is an important problem in location-based services (LBS) and has been well studied on static road networks. However, in real world, road networks are often time-dependent; i.e., the time for traveling through a road ...
Yajun Yang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Improving community structure strategy for efficiently enhancing Internet transmission performance
Tongxin xuebao, 2013 An efficient weakening community structure strategy (WCS) by adding links to the existing networks was propose,which could enhance Internet transmission performance.Internet topology reconstruction could be realized by WCS strategy,because lightpaths ...
Jun CAI, Shun-zheng YU
doaj +2 more sources
Dinamika Rekayasa, 2010 This proposed research concern with application of continuous Hopfield neural networks for shortest path routing in a given map, in this case Purwokerto city’s map had choosen as an example.
Agung Mubyarto, Hesti Susilawati
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