Results 41 to 50 of about 383,776 (277)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cellular Automata Applications in Shortest Path Problem

, 2017
Cellular Automata (CAs) are computational models that can capture the essential features of systems in which global behavior emerges from the collective effect of simple components, which interact locally.
A Macwan, A Nash, AI Adamatzky, Anastasios Tsiftsis, C Nieto-Granda, C. Hochberger, C. Y. Lee, Christian Hochberger, D Ferguson, DB Johnson, EW Dijkstra, Fabio M. Marchese, G Ch Sirakoulis, G Ch Sirakoulis, George S. Fishman, H Beigy, Hong Qu, Ioakeim G. Georgoudas, J Li, J Neumann Von, J-H Liang, K Nagel, K. Ioannidis, Konstantinos Ioannidis, Lazaros Nalpantidis, M Defoort, M.A. Porta Garcia, M.G. Kechaidou, Michail-Antisthenis I Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Nikolaos Dourvas, Nikolaos I. Dourvas, Nikolaos I. Dourvas, O Montiel, PG Tzionas, Q Sun, RW Floyd, S Liu, S Warshall, SK Moghaddam, T Nakagaki, Tiago P. Nascimento, Usman Ahmed Syed, V.S. Kalogeiton, Vasileios G. Ntinas, Vasilis Evangelidis, Vassilios A. Mardiris, Vicky S. Kalogeiton, X Zhang, XGM Wang, XJ Wu, Y Wang   +55 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

On the Maximal Shortest Paths Cover Number

Mathematics, 2021
A shortest path P of a graph G is maximal if P is not contained as a subpath in any other shortest path. A set S⊆V(G) is a maximal shortest paths cover if every maximal shortest path of G contains a vertex of S.
Iztok Peterin, Gabriel Semanišin
doaj   +1 more source

Shortest Paths in Portalgons

, 2023
Any surface that is intrinsically polyhedral can be represented by a collection of simple polygons (fragments), glued along pairs of equally long oriented edges, where each fragment is endowed with the geodesic metric arising from its Euclidean metric.
Löffler, M., Ophelders, Tim, Silveira, Rodrigo Ignacio, Staals, Frank   +3 more
openaire   +8 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Maritime Transport Network in Korea: Spatial-Temporal Density and Path Planning

Journal of Marine Science and Engineering, 2023
The increase in maritime traffic and vessel size has strengthened the need for economical and safe maritime transportation networks. Currently, ship path planning is based on past experience and shortest route usage. However, the increasing complexity of
Jeong-Seok Lee, Tae-Hoon Kim, Yong-Gil Park   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Study on the Shortest Reliable Path of Stochastic Time-Dependent Transportation Networks considering Waiting Time at Signalized Intersections

Journal of Advanced Transportation, 2023
Theoretical research is conducted on finding the shortest path with stochastic and time-dependent characteristics of link travel time in urban road networks.
Yanming Sun, Jie Li, Shixian Liu
doaj   +1 more source