Results 41 to 50 of about 7,690 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On shrinkage estimators improving the James-Stein estimator under balanced loss function

, 2021
In this paper, we are interested in estimating a multivariate normal mean under the balanced loss function using the shrinkage estimators deduced from the Maximum Likelihood Estimator (MLE).
Hamdaoui, Abdenour, Terbeche, Mekki, Benkhaled, Abdelkader   +2 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

From Minimax Shrinkage Estimation to Minimax Shrinkage Prediction

Statistical Science, 2012
Published in at http://dx.doi.org/10.1214/11-STS383 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org)
George, Edward I, Liang, Feng, Xu, Xinyi
openaire   +4 more sources

A new variance estimation in natural exponential families

Research in Statistics
This article focuses on improving the estimation of population variances for natural exponential family distributions, drawing inspiration from the innovative idea presented by Stein.
Arampamoorthy Laheetharan, Nalini Satkunanathan   +1 more
doaj   +1 more source

Interval shrinkage estimation of two-parameter exponential distribution with random censored data [PDF]

Journal of Mahani Mathematical Research
The use of the two-parameter exponential distribution model in fitting survival and reliability analysis data in the presence of censored random data has recently attracted the attention of a large number of authors.
Ali Soori, Parviz Nasiri, Mehdi Jabbari Nooghabi, Farshin Hormozinejad, Mohammadreza Ghalani   +4 more
doaj   +1 more source

Semi-Parametric Estimation Using Bernstein Polynomial and a Finite Gaussian Mixture Model

Entropy, 2022
The central focus of this paper is upon the alleviation of the boundary problem when the probability density function has a bounded support. Mixtures of beta densities have led to different methods of density estimation for data assumed to have compact ...
Salima Helali, Afif Masmoudi, Yousri Slaoui   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Shrinkage Algorithms for MMSE Covariance Estimation [PDF]

IEEE Transactions on Signal Processing, 2010
We address covariance estimation in the sense of minimum mean-squared error (MMSE) for Gaussian samples. Specifically, we consider shrinkage methods which are suitable for high dimensional problems with a small number of samples (large p small n). First, we improve on the Ledoit-Wolf (LW) method by conditioning on a sufficient statistic.
Yilun Chen, Ami Wiesel, Yonina C. Eldar, Alfred O. Hero III   +3 more
openaire   +2 more sources