Results 41 to 50 of about 3,804 (260)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

a simulation comparison of Ridge regression estimators with Lars

پژوهش‌های ریاضی, 2022
Introduction Regression analysis is a common method for modeling relationships between variables. Usually Ordinary Least Squares method is applied to estimate regression model parameters.
Roshanak Alimohammadi, Jaleh Bahari
doaj  

Shrinkage estimates for multi-level heteroscedastic hierarchical normal linear models [PDF]

Journal of Statistical Theory and Applications (JSTA), 2015
Empirical Bayes approach is an attractive method for estimating hyperparameters in hierarchical models. But, under the assumption of normality for a multi-level heteroscedastic hierarchical model, which involves several explanatory variables, the analyst
S.K. Ghoreishi, A. Mostafavinia
doaj   +1 more source

A Meta-Analysis for Simultaneously Estimating Individual Means with Shrinkage, Isotonic Regression and Pretests

Axioms, 2021
Meta-analyses combine the estimators of individual means to estimate the common mean of a population. However, the common mean could be undefined or uninformative in some scenarios where individual means are “ordered” or “sparse”.
Nanami Taketomi, Yoshihiko Konno, Yuan-Tsung Chang, Takeshi Emura   +3 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

A Simulation Study of Some Restricted Estimators in Restricted Linear Regression Model

Tikrit Journal of Pure Science, 2021
When the multicollinearity exists in linear regression model, the result of the Restricted Least Square estimator (RLS) is unstable. So that, more researchers proposed the restricted biased estimators to improve the efficiency of RLS estimator.
Bader Aboud Mohammad, Mustafa Ismaeel Naif   +1 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Improved Efficiency in Generalized Poisson Hurdle Model Estimation Using Restricted and Shrinkage Methods

Journal of Mathematics
This paper investigates the use of shrinkage estimators in the generalized Poisson hurdle (GPH) model for count data analysis. The GPH model effectively handles data with both excess zeros and over- or underdispersion.
Hayder Hasan Rahmah Al-Gharrawi, Hossein Bevrani, Basim Shlaibah Msallam   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source