Results 91 to 100 of about 1,450,984 (187)

Guises of Despair

European Journal of Philosophy, EarlyView.
ABSTRACT In ‘Is Hope A Secular Virtue?’ (2024), Bob Stern and I argued that despairing involves being unable to stop desiring something we deem of great value while believing that this good can neither be obtained, nor return on its own. We characterised despair as one of the two vices hope sits between as a virtue (the opposite vice being unwarranted ...
Béatrice Han‐Pile
wiley   +1 more source

Comparative diagnostic challenges in two horses with skin fragility disorders

Equine Veterinary Education, EarlyView.
Summary Hereditary equine regional dermal asthenia (HERDA) is an autosomal recessive connective tissue disorder of horses caused by a missense mutation (c.115G>A) in the peptidyl‐prolyl cis–trans isomerase B (PPIB) gene, resulting in defective collagen organisation.
M. Biolchi, F. A. Saiki, T. G. Cristo, M. C. Silva, R. J. Souza, A. F. Souza, R. A. Casagrande, J. H. Fonteque, C. I. G. Vogel   +8 more
wiley   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Taxonomic and functional patterns of arthropod succession after glacier retreat in the Dolomite Alps

Insect Conservation and Diversity, EarlyView.
Arthropod succession after glacier retreat varied among species and forelands in the Dolomites Alps, with community composition shaped by glacier identity, time since deglaciation and local environmental conditions. Functional composition shifted from small, highly dispersive pioneer species to larger, less dispersive taxa, reflecting increasing ...
Ivan Petri, Andrea Simoncini, Isabel Cantera, Barbara Valle, Marta Tognetti, Michael Bernasconi, Marina Serena Borgatti, Simone Giachello, Lisa Angelini, Gentile Francesco Ficetola, Silvio Marta, Paolo Pantini, Marco Caccianiga, Mauro Gobbi   +13 more
wiley   +1 more source

Impact of Heat Block Drying on Morphologic Preservation and Staining of Peripheral Blood Smears

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Morphologic evaluation of the peripheral blood smear is critical for diagnosis and ruling out certain hematologic disorders. While air‐drying is standard, some laboratories may use heat blocks to expedite drying. Excessive heat may induce morphologic artifacts, but there is a lack of systematic literature on this practice ...
Ryan C. Shean, Nicolas Mavromatis, Gary Isom, Angie Turnbow, Lauren Pearson   +4 more
wiley   +1 more source

The complexity of kidney disease and diagnosing it - cystatin C, selective glomerular hypofiltration syndromes and proteome regulation. [PDF]

J Intern Med, 2023
Malmgren L, Öberg C, den Bakker E, Leion F, Siódmiak J, Åkesson A, Lindström V, Herou E, Dardashti A, Xhakollari L, Grubb G, Strevens H, Abrahamson M, Helmersson-Karlqvist J, Magnusson M, Magnusson M, Björk J, Nyman U, Ärnlöv J, Ridefelt P, Åkerfeldt T, Hansson M, Sjöström A, Mårtensson J, Itoh Y, Grubb D, Tenstad O, Hansson LO, Olafsson I, Campos AJ, Risch M, Risch L, Larsson A, Nordin G, Pottel H, Christensson A, Bjursten H, Bökenkamp A, Grubb A.   +38 more
europepmc   +1 more source

AI‐Enabled Automated Schistocyte Classification in Peripheral Blood for TMA Auxiliary Diagnosis

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Schistocytes are critical morphological markers for thrombotic microangiopathy (TMA) diagnosis. Manual identification is hampered by inconsistent standards and high interobserver variability, compromising accuracy. Although AI has advanced in hematology, AI‐enabled schistocyte classification remains under‐studied, creating a ...
Lei Shang, Chao Fang, Dongshuo Li, Xuesong Wang, Jiani Yu, Yunchu Cui, Jingliang Chen, Xuekai Liu   +7 more
wiley   +1 more source

European Consortium for Lipodystrophies consensus definition and classification framework for monogenic lipodystrophy

Journal of Internal Medicine, EarlyView.
Abstract Lipodystrophy comprises a heterogeneous group of disorders characterized by reduced adipose tissue often associated with severe metabolic complications. Lipodystrophy may be genetic, acquired, or secondary to medical therapies initiated for other conditions.
Robert K. Semple, Martin Wabitsch, Baris Akinci, Saif Alyaarubi, Marjoleine F. Broekema, Rebecca J. Brown, Giovanni Ceccarini, Carolina Cecchetti, Solaf M. Elsayed, Antía Fernández‐Pombo, Alessandra Gambineri, Ingrid M. Jazet, Lotte Kleinendorst, Konstanze Miehle, Elif A. Oral, Flavia Prodam, Ferruccio Santini, David B. Savage, Nadia Shaukat Ali, Ekaterina Sorkina, Magdalena Szopa, Marie‐Christine Vantyghem, Camille Vatier, Corinne Vigouroux, Julia von Schnurbein, David Araújo‐Vilar   +25 more
wiley   +1 more source

Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
This scheme illustrates the main results of the present study showing an increase in circulating free fatty acids (FFA) that are likely to be related to several mechanisms like decrease in FFA insulin sensitivity and increase in FFA production. Significant changes are labelled in white, and non‐significant or hypothesis are labelled in pale green ...
Anne Briançon‐Marjollet, Marie Netchitaïlo, Fanny Fabre, Elise Belaidi, Claire Arnaud, Anne‐Laure Borel, Patrick Levy, Jean‐Louis Pépin, Renaud Tamisier   +8 more
wiley   +1 more source

Network Analysis in Central Disorders of Hypersomnolence: Insight Into Relationships Between Symptoms, Mental Health, and Quality of Life

Journal of Sleep Research, EarlyView.
Network Analysis in Central Disorders of Hypersomnolence: Insight Into Relationships Between Symptoms, Mental Health, and Quality of Life. ABSTRACT In the central disorders of hypersomnolence (CDH) narcolepsy types 1 and 2 (NT1, NT2) and idiopathic hypersomnia (IH), mental health problems are highly prevalent, and quality of life is decreased.
Denise Bijlenga, Tessa F. Blanken, Josephine J. de Boer, Rolf Fronczek, Gert Jan Lammers   +4 more
wiley   +1 more source