Results 131 to 140 of about 73,247 (279)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Game-based language teaching is vaporware (Part 2 of 2): It’s time to ship or shut down

, 2020
Jonathan deHaan
openalex   +1 more source

Engineering Water-Shut-Off Operations: Application of Rheological Time-Temperature Superposition Approach for Organically-Crosslinked Polymer Gel Systems

, 2023
Mohd. Shahnawaz Alam, Anupal Jyoti Dutta, Prama Adhya, Manish Kaushal   +3 more
openalex   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Engineering Water-Shut-Off Operations: Application of Rheological Time-Temperature Superposition Approach for Organically-Crosslinked Polymer Gel Systems

Mohd. Shahnawaz Alam, Anupal Jyoti Dutta, Prama Adhya, Manish Kaushal   +3 more
openalex   +1 more source

Rheology and gelation kinetics of sulfonated polyacrylamide/Cr(III) acetate gels for water shut-off: effects of salinity, temperature, and shear. [PDF]

Sci Rep
Osmanpour S, Saeedi Dehaghani AH, Behnam Motlagh MA, Simjoo M.   +3 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Power play: This short story by one of Mexico’s most famous contemporary authors is about the irrational exercise of power which shuts down others. Translated into English for the first time [PDF]

, 2018
Yuri Herrera, Jemimah Steinfeld
openalex   +1 more source

Multi-scale studies of oil-water imbibition mechanism on complex pore structures and mixed-wettability: a recent 10-year review. [PDF]

Sci Rep
Liu Q, Wang Q, Liang B, Sun W, Jin J, Liu J, Lei Y, Gao J.   +7 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source