Results 81 to 90 of about 73,247 (279)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Modeling and analysis of hydraulic dashpot for impact free operation in a shut-off rod drive mechanism

Engineering Science and Technology, an International Journal, 2016
Rotary hydraulic dashpot used for shut-off rod drive mechanism application of a nuclear reactor has been studied in this paper for impact free operation.
Narendra K. Singh, Deepak N. Badodkar
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

A shut-in pressure calculation method for high-temperature high-pressure wells in deepwater fractured formations based on thermo-hydro-mechanical coupling

Petroleum Exploration and Development
By comprehensively considering the influences of temperature and pressure on fluid density in high temperature and high pressure (HTHP) wells in deepwater fractured formations and the effects of formation fracture deformation on well shut-in afterflow ...
Gang CHEN, Zhiyuan WANG, Xiaohui SUN, Jie ZHONG, Jianbo ZHANG, Xueqi LIU, Mingwei ZHANG, Baojiang SUN   +7 more
doaj   +1 more source

Fluid-Structure Interaction Simulation of Excess Flow Valve Movement at Different Operating Pressures and Gas Flow Rates

Journal of Applied Fluid Mechanics, 2021
Excess Flow Valves (EFV) for gas-stop systems is generally used in natural gas pipelines to prevent possible damages or destruction due to gas leakage. It can be used in a wide operating range of pressure, but the shut-off flow rate could be in various ...
G. Coşkun, H. Pehlivan
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Kick Risk Forecasting and Evaluating During Drilling Based on Autoregressive Integrated Moving Average Model

Energies, 2019
Timely forecasting of the kick risk after a well kick can reduce the waiting time after well shut-in and provide more time for well killing operations.
Hu Yin, Menghan Si, Qian Li, Jinke Zhang, Liming Dai   +4 more
doaj   +1 more source

Scheduling arc shut downs in a network to maximize flow over time with a bounded number of jobs per time period [PDF]

, 2015
Natashia Boland, Thomas Kalinowski, Simranjit Kaur   +2 more
openalex   +1 more source