Results 151 to 160 of about 76,493 (306)
Shut down and reboot-preparing to minimise infection in a post-COVID-19 era. [PDF]
Lancet Digit Health, 2020 McCall B.
europepmc +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Effect of shut-down on the biological activity of active carbon filter beds
, 2007 Badania przeprowadzono na modelu fizycznym filtru pospiesznego ze złożem formowanego węgla aktywnego WG-12 firmy GRYFSKAND. Złoże filtracyjne zostało uaktywnione biologicznie.
Pruss, A.
core
Shut down of the South American summer monsoon during the penultimate glacial. [PDF]
Sci Rep, 2020 Rodríguez-Zorro PA +14 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The peat-to-power plant in Deblois shut down yesterday after the owner failed to
, 1993 The peat-to-power plant in Deblois shut down yesterday after the owner failed to reach an agreement to sell its electricity to Bangor Hydro-Electric ...
core +1 more source
Simulation of Reciprocating Compressor Start-Up and Shut down under Loaded and Unloaded Conditions
, 2012 During the start-up and shut down phase of reciprocating compressors the loads on all components of driven train system are very high. In this paper a method for the calculating the forces on coupling, e-motor, crank shaft as well other components of the
Kacani, Vasillaq
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