Results 181 to 190 of about 6,019,441 (302)

MGL‐Based Drug Conjugate: A Novel Glycan‐Targeting Strategy for Potential Precision Cancer Therapy

ChemistryEurope, Volume 4, Issue 5, May 2026.
An engineered macrophage galactose‐type lectin (MGL)‐based conjugate (mMGL‐vcMMAE), incorporating an exposed cysteine for site‐specific drug linkage, preserves stability, binding profile, and affinity of the native MGL carbohydrate recognition domain. It also selectively targets Tn/STn‐expressing cancer cells and shows recognition of colorectal cancer ...
Carlos D. L. Lima, Rafaela Abrantes, Victor Lorrain, Joana Gomes, Reyes Núñez‐Franco, João P. M. António, Catarina Gomes, Ana Gimeno, Benedita A. Pinheiro, Angelina S. Palma, Jesús Jiménez‐Barbero, Pedro M. P. Gois, Gonzalo Jiménez‐Osés, Sandra J. van Vliet, Celso A. Reis, Filipa Marcelo   +15 more
wiley   +1 more source

Targeting the Sialic acid/Siglec axis: opportunities and challenges in colorectal cancer immunotherapy. [PDF]

J Immunother Cancer
Wang T, Rong C, Sun G, Wang Y.
europepmc   +1 more source

Edible Bird's Nest Attenuates Neuroinflammation and Cognitive Impairment in a Model of Chronic Fatigue Syndrome

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Edible bird's nest (EBN) alleviates chronic fatigue syndrome (CFS)‐like symptoms in a sleep‐deprivation–induced mice model by suppressing neuroinflammation and improving neurobehavioral performance. EBN administration enhances motor and cognitive functions, reduces neuronal necrosis, and preserves synaptic integrity in the prefrontal cortex ...
Xinyuan Wang, Dongliang Wang, Yi Chai, Yijia Zhang, Huihui Wang, Taiqi Qu, Wenrui Zhang, Man Yuan, Shihan Gao, Yanan Sun, Yixuan Li   +10 more
wiley   +1 more source

Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35. [PDF]

Cell Oncol (Dordr)
Hong B, Wang Y, Feng X, Wei L, Huang Y, Zhang X, Xu L, Jin P, Huang L, Li R, Wu X, Li Z, Ye H, Chen T, Wang X, Zhang H.   +15 more
europepmc   +1 more source

High‐Throughput N‐Glycan Analysis by IR‐MALDESI With a 1.5‐kHz Pulsed Mid‐IR Laser

Journal of Mass Spectrometry, Volume 61, Issue 5, May 2026.
ABSTRACT Infrared matrix‐assisted laser desorption electrospray ionization (IR‐MALDESI) is a laser‐based, hybrid ionization source for mass spectrometry, enabling both mass spectrometry imaging (MSI) and high‐throughput screening (HTS). In this work, a 2.2‐ns, 2.72‐μm laser, operating at 1.5 kHz, was integrated into the IR‐MALDESI platform to evaluate ...
Seth M. Eisenberg, Sarah M. Ashbacher, Alexander A. C. Wainwright, Aosheng Gu, R. J. Dwayne Miller, David C. Muddiman   +5 more
wiley   +1 more source

Evaluation of Methods to Quantify Sialic Acid on Glycomacropeptide. [PDF]

Foods
Dirks ML, Hale J, Theiste E, McDougal OM.   +3 more
europepmc   +1 more source

Sialic Acids

Journal of Biological Chemistry, 1971
Harry Schachter, Edward J. McGuire, Saul Roseman   +2 more
openaire   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, Volume 45, Issue 3, Page 455-475, May/June 2026.
ABSTRACT Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Investigation Into the Dynamics of the Cupula in the Vestibular Organ of Adult Zebrafish Using Metabolic Glycoengineering

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The cupula is a membrane within the vestibular organ that senses rotatory accelerations of the head. Metabolic glycoengineering in combination with bioorthogonal labeling demonstrates that in adult zebrafish – being a model for the human inner ear – this membrane is constantly renewed.
Hans Scherer, Andrea Jüngst, Verena F. Schöwe, Anne‐Katrin Gronewald, Valentin Wittmann   +4 more
wiley   +2 more sources

FUT1- and GAL3ST2-mediated cellular glycan remodeling broadly restricts sialic acid-dependent viral infections. [PDF]

Proc Natl Acad Sci U S A
Zhu X, Nakano S, Rao VN, Miranda HA, Spurrier MA, Skavicus S, Luo Z, Heaton NS.   +7 more
europepmc   +1 more source