Results 211 to 220 of about 116,138 (312)

Profiling glycosphingolipid changes in mouse and human cellular models of lysosomal free sialic acid storage disorder. [PDF]

Mol Genet Metab Rep
Sabir MS, Dobrenis K, Rha AK, Pollard L, Leoyklang P, Marrero M, Ciccone C, Hackbarth ME, Huizing M, Wang RY, Gahl WA, Platt FM, Malicdan MCV.   +12 more
europepmc   +1 more source

Advances in the Development of Lipid Nanoparticles for mRNA Delivery

Small Structures, Volume 7, Issue 2, February 2026.
This review provides an integrated overview of mRNA–lipid nanoparticle (LNP) design, including lipid composition, scalable manufacturing, and structure–activity relationships. We highlight strategies for targeted delivery, physicochemical tuning, and high‐throughput screening such as DNA barcoding.
Xing Wang, Letao Xu, Zhenwei Lan, Yue Hui, Yun Liu, Guangze Yang, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Chemoenzymatically Synthesized O‐Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
7‐O‐, 9‐O‐, and 7,9‐di‐O‐acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α‐glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed by O‐acetyl editing by coronaviral hemagglutinin‐esterases (HEs).
Zhiyong Zhang, Ruonan Liang, Kevin C. Hooijschuur, Robert P. de Vries, Zeshi Li, Geert‐Jan Boons   +5 more
wiley   +2 more sources

Development of mumps virus-specific sialidase imaging probes through chemical modifications of sialic acid. [PDF]

Sci Rep
Narimichi Y, Takahashi T, Kurebayashi Y, Otsubo T, Ikeda K, Saito Y, Minami A, Takeuchi H.   +7 more
europepmc   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Mapping the sialic acid-binding sites of LuIII and H-1 parvovirus. [PDF]

J Virol
Busuttil K, Pittman N, Zachary J, Halder S, Geilen L, Singh A, Misseldine A, Kaplonek P, Chipman P, Heimburg-Molinaro J, Seeberger PH, Mietzsch M, Bennett AD, McKenna R.   +13 more
europepmc   +1 more source

Beyond Total PSA: Clinical Significance of S2,3PSA% in Reducing Unnecessary Prostate Biopsies

International Journal of Urology, Volume 33, Issue 2, February 2026.
ABSTRACT Prostate‐specific antigen (PSA) testing has long been central to prostate cancer detection but is limited by poor specificity, resulting in overdiagnosis and unnecessary prostate biopsies. Although PSA derivatives such as percentage free PSA and the Prostate Health Index (PHI) have improved diagnostic performance, substantial uncertainty ...
Shingo Hatakeyama, Tohru Yoneyama, Chikara Ohyama   +2 more
wiley   +1 more source

Sialic Acid-Containing Glycolipids Extend the Receptor Repertoire of Enterovirus-D68. [PDF]

ACS Infect Dis
Pereirinha da Silva AK, van Trijp JP, Montenarie A, Fok JA, Sooksawasdi Na Ayudhya S, Pieters RJ, Boons GJ, van Riel D, de Vries RP, Bauer L.   +9 more
europepmc   +1 more source

Characterising the Transcriptomic Response to Interferon and Infection in European Domestic Ferret Respiratory Tissues Using Long‐Read RNA Sequencing

Immunology, Volume 177, Issue 2, Page 299-316, February 2026.
We utilised long‐read Nanopore sequencing to characterise the transcriptome of ferret cell lines stimulated with IFN‐α as well as nasal turbinates from ferrets infected with influenza A virus. We identified novel genes and isoforms and observed elongation of poly(A) tails in the ribosome and Coronavirus Disease‐19 pathways in response to IFN‐α ...
Rubaiyea Farrukee, Jessie J.‐Y. Chang, Jianshu Zhang, James B. Barnes, Shu Xin Zhang, Sher Maine Tan, Patrick C. Reading, Lachlan J. M. Coin   +7 more
wiley   +1 more source

The physiological characteristics and applications of sialic acid. [PDF]

NPJ Sci Food
Wang B, Zhang T, Tang S, Liu C, Wang C, Bai J.   +5 more
europepmc   +1 more source