Results 291 to 300 of about 113,461 (351)

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, Volume 58, Issue 10, October 2025.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

Replacing protruding domains of MrNV virus-like particles with sialic acid binding domains enhances binding to SARS-CoV-2 susceptible cells and reduces pseudovirus infection. [PDF]

Sci Rep
Boonkua S, Thongsum O, Chantunmapitak R, Soongnart P, Jaranathummakul S, Srisanga K, Wongtrakoongate P, Asuvapongpatana S, Weerachatyanukul W, Watthammawut A, Somrit M.   +10 more
europepmc   +1 more source

Group A Streptococcus interacts with glycosaminoglycans via M proteins to modulate bacterial adherence in vitro

The FEBS Journal, Volume 292, Issue 20, Page 5540-5562, October 2025.
Interactions between bacteria and the extracellular matrix are a prerequisite for colonisation and infection. Phylogenetically diverse M proteins of group A Streptococcus (GAS) can selectively bind sulfated glycosaminoglycans with high affinity. M protein‐mediated recruitment of chondroitin sulfate and dermatan sulfate was shown to increase GAS ...
Tahnee B.‐D. McEwan, David M. P. De Oliveira, Emily K. Stares, Lauren E. Hartley‐Tassell, Christopher J. Day, Mark J. Walker, Michael P. Jennings, Ronald Sluyter, Martina L. Sanderson‐Smith   +8 more
wiley   +1 more source

The Role of Non-Human Sialic Acid Neu5Gc-Containing Glycoconjugates in Human Tumors: A Review of Clinical and Experimental Evidence. [PDF]

Biomolecules
Blanco R, Muñoz JP.
europepmc   +1 more source

Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship

Influenza and Other Respiratory Viruses, Volume 19, Issue 10, October 2025.
ABSTRACT Background Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against coronaviruses, clarify molecular effects via bioassays and docking, and explore structure–activity relationships.
Marcela Safratova, Yu‐Li Chen, Anna Hostalkova, Jakub Chlebek, Chung‐Fan Hsieh, Bing‐Hung Chen, Lucie Cahlikova, Stefan Kosturko, Anders Backlund, Jim‐Tong Horng, Tsong‐Long Hwang, Michal Korinek   +11 more
wiley   +1 more source

Synthesis of α,ε-<i>N</i>,<i>N</i>'-Di-stearoyl Lysine-Derived Amide Lipids and Their Application to Liposome Formulation: Incorporation of Lipid A-Ligand for Bacterial Targeting and Sialic Acid for Phagocytosis Resistance. [PDF]

Int J Mol Sci
Williams D, McAdorey A, Lei E, Beaudoin G, Ling B, Callaghan D, Fatehi D, Verner A, Slinn J, Moreno M, Iqbal U, Qian H, Yan H, Chen W, Zou W.   +14 more
europepmc   +1 more source

Improved ESI-MS Sensitivity via an Imidazolium Tag (DAPMI-ITag) for Precise Sialic Acid Detection in Human Serum and CMAH-Null Mouse Tissues. [PDF]

Anal Chem
Zhang YY, Hu ZX, Zhang SY, Liu L, Galan MC, Voglmeir J, Ghirardello M.   +6 more
europepmc   +1 more source

On the function of TRAP substrate-binding proteins: Conformational variation of the sialic acid binding protein SiaP. [PDF]

J Biol Chem
King-Hudson TJ, Davies JS, Quan S, Currie MJ, Tillett ZD, Copping J, Panjikar S, Friemann R, Allison JR, North RA, Dobson RCJ.   +10 more
europepmc   +1 more source

An RNase III-processed sRNA coordinates sialic acid metabolism of <i>Salmonella enterica</i> during gut colonization. [PDF]

Proc Natl Acad Sci U S A
Chen Z, Yang Y, Chen X, Bei C, Gao Q, Chao Y, Wang C.   +6 more
europepmc   +1 more source

Sialic acid in the regulation of blood cell production, differentiation and turnover. [PDF]

Immunology
Irons EE, Gc S, Lau JTY.
europepmc   +1 more source