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Structure-Function Relationships of the CMP-Sialic Acid Transporter through Analysis of a Pathogenic Variant in an Alternatively Spliced Functional Isoform. [PDF]
ACS OmegaVelázquez-Dodge BI +7 more
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2014
Sialic acids are nine-carbon acidic monosaccharides found in terminal position of glycan chains. The sialylation of cell surface glycoconjugates is frequently altered in cancers, resulting in the expression of sialylated tumor-associated carbohydrate antigens that are specific markers for this disease.
Delannoy, Philippe, Julien, Sylvain
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Sialic acids are nine-carbon acidic monosaccharides found in terminal position of glycan chains. The sialylation of cell surface glycoconjugates is frequently altered in cancers, resulting in the expression of sialylated tumor-associated carbohydrate antigens that are specific markers for this disease.
Delannoy, Philippe, Julien, Sylvain
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Turnover of Free Sialic Acid, CMP‐Sialic Acid, and Bound Sialic Acid In Rat Brain
Journal of Neurochemistry, 1981Abstract: Adult male rats were injected intraventricularly with N‐[3H]acetylmannosamine. After different time intervals the rats were killed and free sialic acid, CMP‐sialic acid, lipid‐ and protein‐bound sialic acid were isolated from brain and the specific radioactivities determined. Maximal specific radioactivity was reached after approximately 4 h
Wijnholt Ferwerda +2 more
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Glycoconjugate Journal, 1999
The increasing number of reports on the presence of sialic acids in fungi (N-acetyl-, N-glycolyl- and 5,9-N,O-diacetylneuraminic acids) based on direct and indirect evidence warrants the present review. Formerly suggested as sialidase-sensitive sources of anionic groups at the cell surface of fungal species grown in chemically defined media (e.g ...
Roland Schauer +2 more
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The increasing number of reports on the presence of sialic acids in fungi (N-acetyl-, N-glycolyl- and 5,9-N,O-diacetylneuraminic acids) based on direct and indirect evidence warrants the present review. Formerly suggested as sialidase-sensitive sources of anionic groups at the cell surface of fungal species grown in chemically defined media (e.g ...
Roland Schauer +2 more
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Glycobiology, 1991
Cytidine 5'-monophosphosialic acid (CMP-sialic acid) is the activated form of sialic acid which is required for the biosynthesis of sialic acid-containing complex carbohydrates. Its discovery over 30 years ago by the laboratory of Dr Saul Roseman was a landmark in research dealing with the biosynthesis of these compounds.
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Cytidine 5'-monophosphosialic acid (CMP-sialic acid) is the activated form of sialic acid which is required for the biosynthesis of sialic acid-containing complex carbohydrates. Its discovery over 30 years ago by the laboratory of Dr Saul Roseman was a landmark in research dealing with the biosynthesis of these compounds.
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2019
Sialic acid (Sia) is involved in many biological activities and commonly occurs as a monosialyl residue at the nonreducing terminal end of glycoconjugates. The loss of activity of UDP-GlcNAc2-epimerase/ManNAc kinase, which is a key enzyme in Sia biosynthesis, is lethal to the embryo, which clearly indicates the importance of Sia in embryogenesis ...
Ken Kitajima, Chihiro Sato
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Sialic acid (Sia) is involved in many biological activities and commonly occurs as a monosialyl residue at the nonreducing terminal end of glycoconjugates. The loss of activity of UDP-GlcNAc2-epimerase/ManNAc kinase, which is a key enzyme in Sia biosynthesis, is lethal to the embryo, which clearly indicates the importance of Sia in embryogenesis ...
Ken Kitajima, Chihiro Sato
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The acidities of ascorbic and sialic acids
Journal of Chemical Education, 1970This note concerning the pKa's of ascorbic and sialic acids id presented since the compounds are of general interest to organic chemists and carbohydrate chemists as well as biochemists.
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[10] Determination of sialic acids
1994Publisher Summary This chapter describes isolation, purification, and characterization of monomeric sialic acids. There are two basic procedures for liberating sialic acids from glycosidic linkages—enzymatic and acid hydrolysis. In the former case, a variety of sialidases may be used, which differ in specificity for sialic acid linkage or species ...
Gerd Reuter, Roland Schauer
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Nonulosaminic Acid (Sialic Acid) in Protists
Nature, 1960NONULOSAMINIC ACID1, a group of simple and substituted 9-carbon sugars containing nitrogen, was thought restricted to mammals until it was found in the supernates of Escherichia coli and Citrobacter freundii cultures, but not in the supernates of Salmonella, Shigella, Pneumococcus or Bacillus cultures2.
Stuart A. Aaronson +3 more
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