Results 101 to 110 of about 484,885 (328)

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders. [PDF]

, 2019
Identification of genetic biomarkers associated with autism spectrum disorders (ASDs) could improve recurrence prediction for families with a child with ASD.
Brian, J, Bryson, SE, Buchanan, JA, D'Abate, L, Davies, RW, Dobkins, K, Howe, J, Landa, R, Leef, J, Messinger, D, Ozonoff, S, Scherer, SW, Smith, IM, Stone, WL, Tammimies, K, Thiruvahindrapuram, B, Walker, S, Warren, ZE, Wei, J, Young, G, Yuen, RKC, Zwaigenbaum, L   +21 more
core   +2 more sources

Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning

Advanced Science, EarlyView.
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao, Guiyuan Shi, Ruixue Qin, Yinghao Sun, Wenbo Guo, Ruixia Shi, Minxian Peng, Jingxuan Yang, Jianjian Zhao, Qiuhan Liu, Jun Xiao, Ke Zhang, Qiang Liu, Wenxing Yang, He Liu   +14 more
wiley   +1 more source

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

The self-esteem and anxiety of children with and without mentally retarded siblings

Journal of Research in Medical Sciences, 2013
Background: The study was carried out with the aim of determining the factors affecting and to evaluate anxiety situations and self-esteem of children with and without mentally retarded siblings.
Fatma Saban, Duygu Arikan
doaj  

The Negative Effect of Siblings on Perspective-Taking in Adulthood under Chinese Culture

Behavioral Sciences
Evidence from Western developed countries has consistently found that children with sibling(s) showed better perspective-taking (PT) than only children. However, this was not the case in developing countries like China. Our study investigates whether the
Xingyu Fan, Yi Liu
doaj   +1 more source

Are elder siblings helpers or competitors? Antagonistic fitness effects of sibling interactions in humans

Proceedings of the Royal Society B: Biological Sciences, 2013
Determining the fitness consequences of sibling interactions is pivotal for understanding the evolution of family living, but studies investigating them across lifetime are lacking. We used a large demographic dataset on preindustrial humans from Finland
Aïda Nitsch, Charlotte Faurie, V. Lummaa   +2 more
semanticscholar   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

The older sibling effect: comparing social functioning outcomes for autistic children with typically developing siblings, no siblings, and autistic siblings

Frontiers in Psychology
BackgroundPrevious research showed that having older, typically developing (TD) siblings is associated with better social functioning in autistic children.
Yonat Rum, Adi Dolev, Ofri Reichmann, Ditza A. Zachor, Ditza A. Zachor, Einat Avni, Michal Ilan, Michal Ilan, Gal Meiri, Gal Meiri, Judah Koller   +10 more
doaj   +1 more source

Attachment to the Romantic Partner and Sibling: Attachment Hierarchies of Twins and Non-Twin Siblings

Interpersona: An International Journal on Personal Relationships, 2015
Previous studies have shown that romantic partners and siblings are important attachment figures. This study compares the attachment to the romantic partner with the attachment to the sibling as a function of the participant’s sibling type among ...
Sascha Schwarz, Maida Mustafić, Sonja Junker   +2 more
doaj   +1 more source