Results 151 to 160 of about 46,933 (301)

Effects of the angle of head‐down tilt on dynamic cerebral autoregulation during combined exposure to cephalad fluid shift and mild hypercapnia

Experimental Physiology, EarlyView.
Abstract Astronauts experience combined exposure to a cephalad fluid shift and mild hypercapnia during space missions, potentially contributing to health problems. Such combined exposure may weaken dynamic cerebral autoregulation. The magnitude of cephalad fluid shift varies between individuals, and dynamic cerebral autoregulation may be affected more ...
Tomokazu Kato, Yojiro Ogawa, Ken‐ichi Iwasaki   +2 more
wiley   +1 more source

Carotid artery dissection linked to intermittent apnoeic swimming: A case–control study

Experimental Physiology, EarlyView.
Abstract Internal carotid artery (ICA) dissection is a rare and potentially devastating cause of cerebral ischaemia, initiated by an intimal tear or rupture of the vasa vasorum, that can lead to an intraluminal thrombus, vascular stenosis, occlusion, or dissecting aneurysm formation.
Damian M. Bailey, Richard G. Davies, Brenig L. Gwilym, Benjamin S. Stacey, Danny Walmsley, Michael H. Lewis, Josip Butkovic, Ivan Mumlek, Brad Perry, Zvonomir Vrselja, Shigehiko Ogoh, James A. Pawelczyk, Mohamad Bashir, Richard D. White, Ian M. Williams   +14 more
wiley   +1 more source

Influence of facial cooling on carotid body tonic activity and sensitivity

Experimental Physiology, EarlyView.
Abstract Facial cooling can increase ventilation and augment the hypoxic ventilatory response. Whole body cooling increases both carotid body tonic activity and sensitivity; however, whether isolated facial cooling induces similar carotid body hyperexcitability was unknown.
Robyn Morley, Liam D. Corr, Elliott J. Jenkins, Joseph A. Killick, Travis D. Gibbons, Joshua C. Tremblay   +5 more
wiley   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source

Repolarization adaptation to rapid change in heart rate in human models – a review

The Journal of Physiology, EarlyView.
Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt, Karl‐Jonas Axelsson, Pia Dahlberg, Farzad Vahedi, Gunilla Lundahl, Lennart Gransberg   +5 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1807-1813, August 2026.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

Atrial High‐Rate Episodes Mirror Atrial Fibrillation in Stroke Prediction: Evidence From an Indian Prospective Cohort

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
This prospective matched cohort study, which generates hypotheses, finds that device‐detected AF lasting under 24 h is linked to a notably increased risk of stroke/TIA and progression to clinical AF among Indian patients. ABSTRACT Aims To assess the risk of stroke/TIA and progression to atrial fibrillation (AF) in Indian patients with device‐detected ...
Sedhupathi Shanmugam, Sreevilasam P. Abhilash, Jyothi Vijay, Sapna erat Sreedharan, Narayanan Namboodiri   +4 more
wiley   +1 more source