Results 221 to 230 of about 4,991,463 (296)

Pharmacogenomics and Opioid Efficacy in Sickle Cell Disease: Is the Field Ready for Precision Prescribing? [PDF]

J Pers Med
Jaja C, Sop DM, Campbell A, Smith WR.
europepmc   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Structural compression and entorhinal vulnerability: Linking tentorial adjacency to tau burden and dementia progression

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Early neurofibrillary tau degeneration in the entorhinal cortex (EC) is a hallmark of Alzheimer's disease (AD) and aging. We propose a biomechanical cascade hypothesis, suggesting proximity to the tentorial incisura (TI) may render the EC susceptible to chronic mechanical stress, potentially contributing to tau pathology.
Luyue Zhang, Ana M. Franceschi, John F. Crary, Frank A. Provenzano, for the Alzheimer's Disease Neuroimaging Initiative   +4 more
wiley   +1 more source

Proximal tubulopathy in adult sickle cell disease: association of alpha-1 microglobulin. [PDF]

Clinics (Sao Paulo)
Engole YM, Nlandu YM, Nkodila AN, Makanzu B, Mvita Y, Ngoy GM, Mansoni BM, Mvibudulu R, Lukoki B, Nyemba SM, Kinja LZ, Sumaili EK.   +11 more
europepmc   +1 more source

Traditional Uses, Phytochemistry, and Multi‐Target Pharmacological Activities of Senna alexandrina

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Senna alexandrina is a medicinally important plant with documented use across Traditional Chinese, Islamic, Ayurvedic, and Unani medicine systems. Phytochemical investigations have yielded 219 characterized compounds, predominantly anthraquinones, flavonoids, and polysaccharides, distributed across leaves, pods, and aerial parts.
Diana Afrina Rella, Khai‐Lin Hew, Yeun‐Mun Choo   +2 more
wiley   +1 more source

The Unfinished Story of Sickle Cell Nephropathy: A Narrative Review of Knowledge Gaps and Research Imperatives. [PDF]

J Clin Med
Somaili M.
europepmc   +1 more source

The Role of Ferroptosis Induced by Iron Overload in Osteoblast and Osteoclast Function

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Iron overload disrupts bone homeostasis by suppressing osteoblast survival and mineralization, while promoting osteoclastogenesis. As a programmed cell death driven by iron‐dependent lipid peroxidation and glutathione peroxidase 4 (GPX4) downregulation. This study investigated the role of ferroptosis in bone cells under iron overload. Exposure
Supagarn Sooksawanwit, Kornkamon Lertsuwan, Natnicha Tannop, Ploypapus Lapatkeattisukul, Thanayuth Jenpichitkulchai, Nittiyaporn Sotapong, Jarinthorn Teerapornpuntakit, Tueanjai Khunluck, Siriwan Punvilai, Narattaphol Charoenphandhu   +9 more
wiley   +1 more source

Blood Transfusion and ABO Blood Groups in Sickle Cell Disease. [PDF]

Medicina (Kaunas)
Alsalman M, AlSahlawi M, Abid N, Elzorkany K, Abdallah E, AlQuraini A, Alkhalifa HA, Shafey M, Alsalman Z.   +8 more
europepmc   +1 more source

Ultrasound-Guided Peripheral Venous Catheter for Automated Erythrocytapheresis in a Paediatric Population Affected by Sickle Cell Disease. [PDF]

EJHaem
Ocello L, Pavan F, Ferrari GM, Guerra F, Moretto A, Tassistro E, Valsecchi MG, Lepri I, Gregorio L, Passoni A, Balduzzi A, Baldini V, Corti P.   +12 more
europepmc   +1 more source

Optimized Genome‐Wide Profiling of Centromeric Chromatin Complexes by ChIP‐seq

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract Centromeres are specialized chromosomal regions essential for faithful chromosome segregation and genome stability. Their highly repetitive DNA composition and epigenetically defined chromatin state present significant challenges for genome‐wide profiling approaches such as chromatin immunoprecipitation followed by sequencing (ChIP‐seq ...
Alessia Daponte, Rachel Schwope, Caterina Manzari, Lucia Trisolini, Francesca Antonacci, Michele Morgante, Mario Ventura, Glennis A. Logsdon, Claudia R. Catacchio   +8 more
wiley   +1 more source