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Five Steps to Safer Blood Transfusions if You Have Sickle Cell Disease

If you have sickle cell disease (SCD), you may need one or more blood transfusions (healthy blood from a donor put into your body) during your lifetime. During a blood transfusion, your blood and the donated blood must have matching antigens, or special ...

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Sustained expression of hemopexin in an animal model of sickle cell anemia. [PDF]

Blood Vessel Thromb Hemost
De Lima F, De Moraes CRP, Borba-Junior IT, Assalin HB, Abdalla Saad MJ, Costa FF, De Paula EV.   +6 more
europepmc   +1 more source

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, Volume 208, Issue 6, Page 2203-2211, June 2026.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Reliability of diffuse optical spectroscopies for evaluation of cerebral hemometabolic stress in children with sickle cell anemia. [PDF]

Biomed Opt Express
Martins GG, Brothers RO, Wubbena K, Akbar M, Arrington M, Turrentine KB, Triplett S, Zhao H, Urner TM, Bai S, Tang A, Khemani K, Gee BE, Brown RC, Buckley EM.   +14 more
europepmc   +1 more source

A Phase 1 Microtracer Study Evaluating the Mass Balance, Excretion, and Pharmacokinetics of Osivelotor in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Osivelotor (GBT021601) is an orally bioavailable, small molecule hemoglobin polymerization inhibitor in clinical development for the treatment of sickle cell disease (SCD). In this Phase 1 study, the disposition of osivelotor was assessed using accelerator mass spectrometry (AMS) after a single oral 200‐mg dose containing a microtracer amount ...
Eric I. Zimmerman, Ernesto Callegari, Raman Sharma, Adeyemi Adenola, Jessica Volpe, Karthik Seetharaman, Chenghong Zhang, Kenneth Duchin, Gregory S. Walker   +8 more
wiley   +1 more source

BCL11A and HBS1L-MYB polymorphisms, in association with hydroxyurea and sex, modulate fetal hemoglobin levels in individuals with sickle cell anemia in the western region of Bahia, Brazil. [PDF]

Mol Biol Rep
de Magalhães Filho MF, Santana ILR, da Silva PLP, Venancio LPR.   +3 more
europepmc   +1 more source

Eye problems and sickle cell trait : learn how you can help protect your vision [Spanish]

Eye problems and sickle cell trait : learn how you can help protect your vision [Spanish]FS_Glaucoma_LAY-es-508 ...

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Acute Exercise Challenge and Airway Dynamics in Youth With Sickle Cell Anemia: A Multicenter Study. [PDF]

Am J Hematol
Cohen RT, Hankins JS, Ness KK, Hsu LL, Baynard T, Tang A, Radom-Aizik S, Guerrero K, Rodeghier M, Liem RI.   +9 more
europepmc   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 521-530, June 2026.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Get screened to know your sickle cell status [French]

Get screened to know your sickle cell status [French]POUR SAVOIR SI VOUS OU VOS PROCHES e\u302tes atteints de la dre\u301panocytose ou porteurs d\u2019un ge\u300ne de la dre\u301panocytose, des tests sanguins doivent e\u302tre faits. Le fait d\u2019avoir

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