Advanced Science, EarlyView.Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu +11 more
wiley +1 more source
Advanced Science, EarlyView.Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas +6 more
wiley +1 more source
The association between pain and diagnosis-specific long-term sickness absence at different levels of body mass index - a register-linked cohort study. [PDF]
BMC Public HealthFagerlund P +5 more
europepmc +1 more source
ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals
Advanced Science, EarlyView.The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray +3 more
wiley +1 more source
Predictors of prolonged sickness absence after work injuries: a retrospective study using Tukey's Fence in 66,658 Hong Kong workers. [PDF]
BMC Public HealthWan Z +6 more
europepmc +1 more source
Defect‐Functionalization‐Mediated Tunneling Drives Nonlinear Photoemission in Perovskites
Advanced Science, EarlyView.This cover illustration depicts CsPbBr3 perovskite nanocrystals embedded with functionalized defect vacancies, where electrons migrate through defect‐mediated pathways and emit as lightning‐like beams. The imagery visualizes the core discovery of our work—defect‐functionalization‐mediated tunneling enabling nonlinear photoemission, where deep‐level ...
Hang Ren +9 more
wiley +1 more source
Correction: Examining associations between upsizing, downsizing, workplace offensive behaviors and sickness absence due to common mental disorders - a longitudinal cohort study. [PDF]
BMC Public HealthWijkander M +3 more
europepmc +1 more source
, 2012 Beleid bij ziekteverzuim richt zich vaak op langdurig zieken. Jolanda Schreuder stelt dat organisaties en bedrijven er goed aan doen om meer aandacht te schenken aan medewerkers die regelmatig kortdurend ziek zijn, en medewerkers die nooit afwezig zijn.
openaire +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Genetic Code Expanded T Cell for Controllable Immunotherapy
Advanced Science, EarlyView.Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang +4 more
wiley +1 more source