Results 251 to 260 of about 1,994,819 (333)

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

open access: yesAdvanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang   +13 more
wiley   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

open access: yesAdvanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang   +10 more
wiley   +1 more source

Line manager perspectives on workplace-based efforts to reduce sickness absence: a qualitative study. [PDF]

open access: yesInt J Qual Stud Health Well-being
Rasmussen L   +3 more
europepmc   +1 more source

Bidirectional Photoadaptive Organic Heterojunction Synaptic Transistors for Accurate Image Recognition in Machine Vision Systems

open access: yesAdvanced Science, EarlyView.
Bidirectional photoadaptive organic synaptic phototransistors are developed using complementary n–n and n‐p heterojunctions. These devices enable intelligent in‐sensor processing, markedly enhancing image contrast and edge features under adverse lighting, and achieve a recognition accuracy of 97.4% within ten training cycles for machine vision ...
Di Xue   +9 more
wiley   +1 more source

Incidence Rates of Medically Certified Long-term Sickness Absence Among Japanese Employees: A Focus on Sex Differences. [PDF]

open access: yesJ Epidemiol
Taniyama Y   +18 more
europepmc   +1 more source

Droplet Digital CRISPR for Nucleic Acid Detection

open access: yesAdvanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang   +4 more
wiley   +1 more source

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