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Human sickness behavior: Ultimate and proximate explanations
American Journal of Physical Anthropology, 2015ABSTRACTSickness behavior, a coordinated set of behavioral changes in response to infection, lies at the intersection of immunology, endocrinology, and evolutionary biology. Sickness behavior is elicited by pro‐inflammatory cytokines, is thought to be an adaptive means of redirecting energy away from disadvantageous behaviors and toward mounting an ...
Eric C. Shattuck, Michael P. Muehlenbein
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Health Behavior, Illness Behavior, and Sick-Role Behavior
Archives of Environmental Health: An International Journal, 1966(1966). Health Behavior, Illness Behavior, and Sick-Role Behavior. Archives of Environmental Health: An International Journal: Vol. 12, No. 4, pp. 531-541.
S V, Kasl, S, Cobb
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Cytokines and Sickness Behavior
Annals of the New York Academy of Sciences, 1998Abstract: Peripheral and central injections of interleukin‐1 (IL‐1) and lipopolysaccharide (LPS) induce the expression of proinflammatory cytokines in the brain and have profound depressing effects on spontaneous and learned behaviors. These effects are mediated by vagal afferents, because they are abrogated by section of the vagus nerves at the ...
Dantzer, Robert +5 more
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Cytokine-induced sickness behavior
Brain, Behavior, and Immunity, 2003The behavioral repertoire of humans and animals changes dramatically following infection. Sick individuals have little motivation to eat, are listless, complain of fatigue and malaise, loose interest in social activities and have significant changes in sleep patterns.
Kelley, K.W. +6 more
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Cytokines and Sickness Behavior
European Neuropsychopharmacology, 1991Non specific symptoms of infection and inflammation include fever and profound physiological and behavioral changes. Sick individuals experience weakness, malaise, listlessness and inability to concentrate. They become depressed and lethargic, show little interest in their surroundings and stop eating and drinking.
Dantzer, Robert +3 more
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Understanding a Sick Childʼs Behavior
AJN, American Journal of Nursing, 1948R CENT developments in psychiatry have repeatedly emphasized that the emotional disturbances of adults are directly related to the conflicts, stresses, strains, and traumatic experiences of childhood. A pediatric nurse observing children in the hospital situation is confronted daily with signs of emotional distress precipitated by the child's illness ...
M, WALLACE, V, FEINAUER
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Molecular Basis of Sickness Behaviora
Annals of the New York Academy of Sciences, 1998ABSTRACT: Peripheral and central injections of lipopolysaccharide (LPS), a cytokine inducer, and recombinant proinflammatory cytokines such as interleukin‐1β (IL‐1β) induce sickness behavior in the form of reduced food intake and decreased social activities.
Dantzer, Robert +6 more
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Veterinary Clinics of North America: Food Animal Practice, 1987
The behavior of the sick animal is not necessarily a result of physical debilitation; it can be viewed as part of a highly organized adaptive strategy that is at times critical to survival if the animal were living in the wild state. Domestic ruminants appear to have retained this behavioral mode when they are sick. This article brings together several
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The behavior of the sick animal is not necessarily a result of physical debilitation; it can be viewed as part of a highly organized adaptive strategy that is at times critical to survival if the animal were living in the wild state. Domestic ruminants appear to have retained this behavioral mode when they are sick. This article brings together several
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Characterization of sickness behavior in zebrafish
Brain, Behavior, and Immunity, 2018In a previous study we showed a clear relationship between immune system and behavior in zebrafish and we hypothesized that the immune system is capable of inducing behavioral changes. To further investigate this subject and to address our main question, here we induced an inflammatory response in one group of fish by the inoculation of formalin ...
Karina, Kirsten +4 more
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