Results 151 to 160 of about 2,166,400 (310)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Side effects and cessation of the oral contraceptive pill on TikTok: a content analysis. [PDF]

Front Reprod Health
Ilori M, Lee H, Patel A, Stanton T.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Efficacy and side effects of long-term treatment strategies of canine primary hypoadrenocorticism. [PDF]

Front Vet Sci
Dobosz DA, Zablotski Y, Wehner A.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Prevalence and predictive testing preferences for breast cancer treatment side effects. [PDF]

Support Care Cancer
McCall MK, Destin D, Miller ME, Schumacher FR, Thompson CL.   +4 more
europepmc   +1 more source

Methylphenidate Side Effects

Journal of the American Academy of Child & Adolescent Psychiatry, 1988
openaire   +2 more sources

A cross sectional survey of side effects of antiretroviral (ARV) in outpatients HIV by Naranjo Algorithm

, 2021
Oki Nugraha Putra, Oki Nugraha Putra
openalex   +2 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Targeting Dermatologic Side Effects of Immunotherapy Using Novel Skin Care Products. [PDF]

J Cancer
Claes M, Lodewijckx J, Robijns J, Tuts L, Lenaerts M, Vandaele E, Wessels T, Requilé A, Luyten D, Verheezen Y, Joosens E, Mebis J.   +11 more
europepmc   +1 more source