Results 101 to 110 of about 10,662,693 (288)

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy

, 2012
Learning and memory dysfunction is the most common neuropsychological effect of mesial temporal lobe epilepsy, and because the underlying neurobiology is poorly understood, there are no pharmacological strategies to help restore memory function in these ...
Shtaya, Anan, Taylor, Matthew, Hamilton, Derek A., Gray, William Peter, Barkas, Lisa, Redhead, Edward, Gray, William P.   +6 more
core   +1 more source

Distinct Cleavage Trajectories Mediated by DNA and RNA Substrate in Argonaute From Methanocaldococcus Fervens

Advanced Science, EarlyView.
This study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Fuyong Huang, Taiyu Chen, Meng Fang, Qinmiao Duanmu, Kangle Mu, Yuqi Bi, Siwei Xu, Xin Tao, Jiening Wang, Shan Wu   +9 more
wiley   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Design of Beam-Forming Networks for Fermat Spiral Antenna Arrays

Technologies
This paper presents a novel design technique using beam-forming networks based on CORPS (coherently radiating periodic structures) technology to achieve the simplification of the feed network of Fermat spiral antenna arrays.
Kleiverg Encino, Marco A. Panduro, Alberto Reyna, David H. Covarrubias, Leopoldo A. Garza   +4 more
doaj   +1 more source

Improvement on Side Lobe Level for self-supported sub-reflector fed antenna systems

, 2018
This work presents significant improvement on Side Lobe Level optimization for self-supported sub-reflector fed systems of compact reflector antennas. The case study presented shows the experimental results of a 1200mm reflector system that operates at ...
Martínez Rodríguez-Osorio, Ramón, Haro Ariet, Leandro de, Nair, Binoy, Salas Natera, Miguel Alejandro   +3 more
core  

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

Advanced Science, EarlyView.
The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang, Benjamin K. Law, Niles Huang, Katharine Goodwin, Celeste M. Nelson, Michelle M. Chan   +5 more
wiley   +1 more source

THE INFLUENCE OF RADIATOR EXCITATION AND POSITION RANDOM ERRORS ON CHARACTERISTICS OF MULTIFACETED ANTENNA ARRAY

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The influence of different types of random errors on radiation pattern and directivity of multifaceted antenna array is considered. The behavior of such parameters as average maximum directivity, average maximum side lobe level and main lobe fluctuation ...
D. V. Moskaliov
doaj  

A Wideband Single-Port Differential-Fed Linear Antenna Array With Low Side Lobe Level and Symmetric Radiation Patterns

IEEE Access
A single-port differential-fed 12-element linear antenna array is developed for wideband millimeter-wave (mmWave) communication systems, with the 28-GHz band as the primary target providing wide frequency bandwidth (FBW), high gain, low side lobe level ...
Mohammad Hadi Moradi Ardekani, Shima Pashangeh   +1 more
doaj   +1 more source

Construction of Waveform Library in Cognitive Radar

Polish Maritime Research, 2017
Based on the thoughts of cognitive radar, Fractional Fourier Transform (FrFT) is used to generate a rotatable waveform libraries of Frank coded/Barker coded waveform in this paper.
Yongqiang Guo, Yumin Wu, Hui Liu
doaj   +1 more source