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Microbial siderophores: a mini review
Journal of Basic Microbiology, 2012AbstractIron is one of the major limiting factors and essential nutrients of microbial life. Since in nature it is not readily available in the preferred form, microorganisms produce small high affinity chelating molecules called siderophores for its acquisition. Microorganisms produce a wide variety of siderophores controlled at the molecular level by
Ratul, Saha +3 more
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Siderophore-dependent ferrichelatases
Iron is a crucial secondary metabolite for bacterial proliferation, but its bioavailability under infection conditions is limited by the low solubility of ferric ion and the host's ability to sequester iron by protein chelation. In these iron limiting conditions, bacteria produce and secrete low molecular weight ferric ion chelators, siderophores, to ...C E, Merrick +2 more
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Recent advances in siderophore biosynthesis
Current Opinion in Chemical Biology, 2009The biosynthesis of the microbial small molecule iron scavengers known as siderophores has been of interest since their discovery in the middle of the past century. Two main pathways for siderophore biosynthesis exist. One is directed by a large family of modular multienzymes called non-ribosomal peptide synthetases (NRPSs) while the other is NRPS ...
Barry, Sarah M., Challis, Gregory L.
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Total Synthesis of the Siderophore Danoxamine
The Journal of Organic Chemistry, 2000The total synthesis of the linear trihydroxamate siderophore, Danoxamine, is described. Danoxamine is a siderophore component of the naturally occurring siderophore-drug conjugates Salmycin A-D. The synthesis of Danoxamine features a series of coupling reactions involving N-(5-benzyloxypentyl)-O-benzylhydroxylamine being linked by a succinoyl linker to
J M, Roosenberg, M J, Miller
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Cefiderocol: a novel siderophore cephalosporin
Expert Opinion on Investigational Drugs, 2018The emergence of multidrug-resistant bacterial pathogens has led to a global public health emergency and novel therapeutic options and drug-delivery systems are urgently needed. Cefiderocol is a siderophore cephalosporin antibiotic that has recently been developed to combat a variety of bacterial pathogens, including β-lactam- and carbapenem-resistant ...
Justin J, Choi, Matthew W, McCarthy
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Monitoring Iron Uptake by Siderophores
2014Iron is an important element for almost all forms of life. In order to get access to this essential nutriment, Pseudomonads produce two major siderophores, pyoverdine PVD and pyochelin (PCH). Uptake of iron in bacterial cells can be monitored accurately using (55)Fe.
Françoise, Hoegy, Isabelle J, Schalk
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2014
This chapter attempts to illustrate the occurrence of siderophores within different bacterial genera and explains the relationship between environmental factors and the biological function of siderophores, which may be summarized under the term "ecology of siderophores".
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This chapter attempts to illustrate the occurrence of siderophores within different bacterial genera and explains the relationship between environmental factors and the biological function of siderophores, which may be summarized under the term "ecology of siderophores".
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Microbial siderophore-mediated transport
Biochemical Society Transactions, 2002Microbial iron chelates, called siderophores, are synthesized by bacteria and fungi in response to low iron availability in the environment. The present review summarizes structural details of siderophore ligands with respect to their transport properties.
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2007
Siderophores, defined as iron(III) specific transport compounds, are widely distributed in aerobic and facultative anaerobic microbial species. The list of microbes known to form siderophores includes various enteric bacteria; human, animal and plant pathogenic bacteria and fungi; soil microorganisms; Gram positive and negative species, blue green alga
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Siderophores, defined as iron(III) specific transport compounds, are widely distributed in aerobic and facultative anaerobic microbial species. The list of microbes known to form siderophores includes various enteric bacteria; human, animal and plant pathogenic bacteria and fungi; soil microorganisms; Gram positive and negative species, blue green alga
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Siderophore production by Salmonella typhi
Biochemical and Biophysical Research Communications, 1988This study was initiated to determine the mechanism of iron-uptake in Salmonella typhi. When stressed for iron, microorganisms produce siderophores to obtain the necessary nutrient. Generally two types of siderophores exist: the phenolate-type predominantly produced by bacteria and the hydroxamate-type commonly secreted by fungi.
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