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BioMetals, 2009
Siderophores are low molecular weight organic ligands exuded by some aerobic organisms and plants to acquire Fe under Fe-limited conditions. The hydroxamate siderophores may sorb to aluminosilicate clays through a variety of mechanisms depending upon the nature of the clay and of the siderophore along with solution conditions such as pH, ionic strength,
Patricia A, Maurice +2 more
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Siderophores are low molecular weight organic ligands exuded by some aerobic organisms and plants to acquire Fe under Fe-limited conditions. The hydroxamate siderophores may sorb to aluminosilicate clays through a variety of mechanisms depending upon the nature of the clay and of the siderophore along with solution conditions such as pH, ionic strength,
Patricia A, Maurice +2 more
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Chemistry and biology of siderophores
Natural Product Reports, 2010Siderophores are compounds produced by bacteria, fungi and graminaceous plants for scavenging iron from the environment. They are low-molecular-weight compounds (500-1500 daltons) possessing a high affinity for iron(III) (Kf > 1030), the biosynthesis of which is regulated by iron levels and the function of which is to supply iron to the cell.
Hider, Robert C., Kong, Xiaole
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Occurrence of Siderophores in Enterococci
Zentralblatt für Bakteriologie, 2000In 70 strains of the genus Enterococcus belonging to 16 species and isolated from clinical material, animals and the environment, a hydroxamic class of siderophores was detected with the aid of chemical and biological tests. A correlation between siderophore activity and species affiliation was found: E.
P, Lisiecki, P, Wysocki, J, Mikucki
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ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
E.A. Dertz, K.N. Raymond
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AbstractFor Abstract see ChemInform Abstract in Full Text.
E.A. Dertz, K.N. Raymond
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Fungal Genetics and Biology, 2015
Efficient iron acquisition mechanisms are fundamental for microbial survival in the environment and for pathogen virulence within their hosts. M. robertsii produces two known iron-binding natural products: metachelins, which are used to scavenge extracellular iron, and ferricrocin, which is strictly intracellular.
Bruno, Giuliano Garisto Donzelli +2 more
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Efficient iron acquisition mechanisms are fundamental for microbial survival in the environment and for pathogen virulence within their hosts. M. robertsii produces two known iron-binding natural products: metachelins, which are used to scavenge extracellular iron, and ferricrocin, which is strictly intracellular.
Bruno, Giuliano Garisto Donzelli +2 more
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Microbial siderophores: a mini review
Journal of Basic Microbiology, 2012AbstractIron is one of the major limiting factors and essential nutrients of microbial life. Since in nature it is not readily available in the preferred form, microorganisms produce small high affinity chelating molecules called siderophores for its acquisition. Microorganisms produce a wide variety of siderophores controlled at the molecular level by
Ratul, Saha +3 more
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Siderophore-dependent ferrichelatases
Iron is a crucial secondary metabolite for bacterial proliferation, but its bioavailability under infection conditions is limited by the low solubility of ferric ion and the host's ability to sequester iron by protein chelation. In these iron limiting conditions, bacteria produce and secrete low molecular weight ferric ion chelators, siderophores, to ...C E, Merrick +2 more
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Recent advances in siderophore biosynthesis
Current Opinion in Chemical Biology, 2009The biosynthesis of the microbial small molecule iron scavengers known as siderophores has been of interest since their discovery in the middle of the past century. Two main pathways for siderophore biosynthesis exist. One is directed by a large family of modular multienzymes called non-ribosomal peptide synthetases (NRPSs) while the other is NRPS ...
Barry, Sarah M., Challis, Gregory L.
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Total Synthesis of the Siderophore Danoxamine
The Journal of Organic Chemistry, 2000The total synthesis of the linear trihydroxamate siderophore, Danoxamine, is described. Danoxamine is a siderophore component of the naturally occurring siderophore-drug conjugates Salmycin A-D. The synthesis of Danoxamine features a series of coupling reactions involving N-(5-benzyloxypentyl)-O-benzylhydroxylamine being linked by a succinoyl linker to
J M, Roosenberg, M J, Miller
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Cefiderocol: a novel siderophore cephalosporin
Expert Opinion on Investigational Drugs, 2018The emergence of multidrug-resistant bacterial pathogens has led to a global public health emergency and novel therapeutic options and drug-delivery systems are urgently needed. Cefiderocol is a siderophore cephalosporin antibiotic that has recently been developed to combat a variety of bacterial pathogens, including β-lactam- and carbapenem-resistant ...
Justin J, Choi, Matthew W, McCarthy
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