Results 61 to 70 of about 138,604 (330)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Synthesis MFI Zeolites Using Alternative Silica Source for CO₂ Capture

Ceramics
In recent years, climate change has attracted the attention of the scientific community. These changes are attributed to human action, which is responsible for the emission of polluting gases, mainly through the burning of fossil fuels, deforestation ...
Clenildo de Longe, Aryandson da Silva, Anne Beatriz Figueira Câmara, Francisco Gustavo Hayala Silveira Pinto, Lindiane Bieseki, Luciene Santos de Carvalho, Sibele Berenice Castellã Pergher   +6 more
doaj   +1 more source

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands [PDF]

, 2012
A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1.
Baker, Benjamin D. Crossley, Charlotte E. Willans, Chen, Corberan, Diana C. F. Monteiro, Dragutan, Hermann, Hickey, Hindi, Jake Fielden, Kascatan-Nebioglu, Klasen, Lin, Magill, Marion, Medvetz, Melaiye, Meres, Mosmann, Patil, Patil, Patil, Patil, Patil, Rai, Ray, Roger M. Phillips, Roland, Siciliano, Teyssot, Teyssot, Willans   +32 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Perfluoropolymer/Molecular Sieve Mixed-Matrix Membranes

Membranes, 2019
Despite the outstanding chemical, thermal and transport properties of amorphous and glassy perfluorinated polymers, only few works exist on the preparation and transport properties of perfluoropolymer/molecular sieves mixed-matrix membranes (MMMs ...
Gianni Golemme, Anna Santaniello
doaj   +1 more source

Fractal photon sieve

Optics Express, 2006
A novel focusing structure with fractal properties is presented. It is a photon sieve in which the pinholes are appropriately distributed over the zones of a fractal zone plate. The focusing properties of the fractal photon sieve are analyzed. The good performance of our proposal is demonstrated experimentally with a series of images obtained under ...
Gimenez, Fernando, Monsoriu, Juan A., Furlan, Walter D., Pons, Amparo   +3 more
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Equations for a potential algebraic approach to the twin prime conjecture. Addendum to: "On the numbers that determine the distribution of twin primes" [PDF]

Surveys in Mathematics and its Applications
This is an Addendum to: Article: On the numbers that determine the distribution of twin primes Author: Antonie Dinculescu Published in: Surveys in Mathematics and its Applications, 13 (2018), 171–181. Full text:
Antonie Dinculescu
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Deuterium distribution in two major products obtained during the cyclic dimerisation of methyloxirane over acidic molecular sieves [PDF]

, 2006
The ring-transformation reactions of methyloxirane on DZSM-5 and DAlMCM-41 aluminosilicates were studied in a pulse microreactor at 363 K. Cyclic dimerisation was found to be the major reaction pathway. Deuterium distribution in two important products of
Fási, András, Pálinkó, István
core