Results 91 to 100 of about 1,565,960 (281)

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Programmable Guest‐Induced 5‐Phase‐Transition Topological Reconstructions of Cobalt Formate Metal–Organic Frameworks

Advanced Science, EarlyView.
A reversible five‐phase topological cycle is achieved in a minimalist cobalt formate metal–organic framework. The amorphous phase functions as a programmable reactive hub, selectively reconstructing into four distinct crystalline architectures through cationic templates, humidity, or CO2.
Zhiyu Tao, Jingjian Li, Jing Ling, Tianxiang Chen, Wing‐Yiu Yu, Cong Lin, Tsz Woon Benedict Lo   +6 more
wiley   +1 more source

Sensing Technologies for Detection of Acetone in Human Breath for Diabetes Diagnosis and Monitoring

Diagnostics, 2018
The review describes the technologies used in the field of breath analysis to diagnose and monitor diabetes mellitus. Currently the diagnosis and monitoring of blood glucose and ketone bodies that are used in clinical studies involve the use of blood ...
Valentine Saasa, Thomas Malwela, Mervyn Beukes, Matlou Mokgotho, Chaun-Pu Liu, Bonex Mwakikunga   +5 more
doaj   +1 more source

SIFT transzformáció statisztikai momentumokkal

, 2016
SIFT transzformáció leíró vektorainak helyettesíthetősége momentumokból képzett vektorokkal.BSc/BAProgramtervező ...
Godó, Tamás
core  

High‐Current‐Density Acidic CO2 Electroreduction to Formic Acid Enabled by Multiscale Microenvironment Regulation Over Defect‐Rich Sn/SnOx

Advanced Science, EarlyView.
Acidic CO2 electroreduction to formic acid is enabled by integrating mixed Sn/SnOx nanoclusters, K+‐regulated interfacial solvation, and Janus wettability. Coordinated control of active sites, interfacial water, and gas‐liquid transport suppresses hydrogen evolution and delivers approximately 85% HCOOH Faradaic efficiency at 400 mA cm−2.
Qiaoqi Guo, Bowen Jiang, Le Huang, Kunyu Jiang, Rongrong Tang, Qinong Zhu, Huajun Feng, Mengyang Fan, Yijing Xia   +8 more
wiley   +1 more source

The SIFT and FALP techniques; applications to ionic and electronic reactions studies and their evolution to the SIFT-MS and FA-MS analytical methods [PDF]

, 2014
Flow tube reactors coupled with quantitative mass spectrometry have made, and continue to make, major contributions to gas phase ion–molecule chemistry, to recombination and electron attachment studies and, most recently, to gas phase trace gas analysis.

core   +1 more source

A Conduction‐Nucleation‐Competition‐Guided 3D Adaptive Gradient Buffer for Dendrite‐Free All‐Solid‐State Lithium Metal Batteries

Advanced Science, EarlyView.
A self‐adaptive gradient SCMN buffer layer is designed based on a conduction‐nucleation competition mechanism. The design dynamically optimizes ion/electron conduction and lithiophilicity, guiding dendrite‐free lithium deposition. Consequently, symmetric cells deliver exceeding 1600h at 1.5 mA cm−2, and the LiCoO2‐based full cells exhibit 98.5 ...
Yaru Shi, Libin Hu, Qiuhong Li, Zheng Zhang, Shoushuang Huang, Bing Zhao, Yi Xu, Zhangjun Hu, Yong Jiang, Jiujun Zhang   +9 more
wiley   +1 more source

Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures

Advanced Science, EarlyView.
ClassiCOL_v2 uses a novel “peptide patching” framework that treats any collagen sample as a patchwork of peptide sequences derived from phylogenetically related species. This allows the algorithm to simultaneously resolve two previously intractable problems: multi‐species samples and/or database deficiencies.
Ian Engels, Tristan Dedrie, Synnøve K. Mo, Simon Van de Vyver, Thijs R. A. Vandenbroucke, Kévin Di Modíca, Jan Decher, Alice Toso, Dieter Deforce, Simon Daled, Alexandra Burnett, Grégory Abrams, Maarten Dhaenens   +12 more
wiley   +1 more source

Advances in Breath Analysis-Based Disease Diagnosis Technology and Standardization Requirements

Zhipu Xuebao
The composition and content of volatile organic compounds (VOCs) in exhaled breath are closely related to change in the human physiological state. Some biosignature molecules generated by human metabolism, including disease marker molecules, are expelled
Wen-quan ZHANG, Lu-lu FENG, Zi-hong YE, Xiao-yun GONG   +3 more
doaj   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source