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Assessing SIFT-MS Method Feasibility (Procedure 1)
The marked difference in the analytical approach of SIFT-MS compared with the conventional GC and LC techniques means that the feasibility of method transfer – or new method development – for SIFT-MS should be evaluated prior to experimental work. Drawing on principles discussed in Part 1 of this book, this chapter describes a procedure by which the ...openaire +1 more source
The Principles of the SIFT-MS Technique
The selected ion flow tube mass spectrometry (SIFT-MS) technique operates on very different principles to the more established chromatographic methods. This chapter provides a comprehensive introduction to how SIFT-MS instruments work, the ion–molecule reaction (IMR) chemistry that provides both comprehensive and specific analysis, and the utilisation ...openaire +1 more source
Modifying an Existing SIFT-MS Method (Procedure 7)
SIFT-MS, with its chromatography-free, soft chemical ionisation approach to the analysis of volatile compounds requires different procedures for modifying validated test methods compared to GC. This chapter provides procedures for modifying SIFT-MS methods involving addition or removal of analytes, modification to product ion selections, a change of ...openaire +1 more source
Design and Implementation of Analytical Mathematics for SIFT-MS Medical Applications
2009Selected Ion Flow Tube-Mass spectrometry (SIFT-MS) is an analytical measurement technology for the real-time quantification of volatile organic compounds in gaseous samples. This technology has current and potential applications in a wide variety of industries, although the focus of this research is in medical science.
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Integrity of Storage Media for Clinical Applications with SIFT-MS Instruments
2006Tedlar™ bags are a promising medium for remote breath collection and later analysis using SIFT-MS for disease diagnosis. It is important to understand the changes in integrity of samples stored in Tedlar™ bags. However, there is little work into this problem completed to date, and thus little known about these issues.
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Preparing the Automated SIFT-MS Instrument for Analysis (Procedure 2)
Selected ion flow tube mass spectrometry (SIFT-MS) instruments have different operational procedures compared to conventional chromatographic instruments, since they are based on different principles. This chapter describes, in a general manner, how to prepare a SIFT-MS instrument for analysis, together with a coupled robotic autosampler. Additionally,openaire +1 more source
Validating SIFT-MS Analysis of Volatiles in Breath
Current Analytical Chemistry, 2013Malina Storer +3 more
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Hmotnostní spektrometrie v proudové trubici s vybranými ionty, SIFT-MS
20134 Abstract This thesis describes research that has been carried out during the years 2009-2013 as a part of my PhD project related to the method of selected ion flow tube mass spectrometry (SIFT- MS) and its application in interdisciplinary areas of research.
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SIFT: predicting amino acid changes that affect protein function
Nucleic Acids Research, 2003Steven Henikoff
exaly