Results 251 to 260 of about 189,815 (388)

‘Sifting the significance from the data’ - the impact of high-throughput genomic technologies on human genetics and health care [PDF]

open access: gold, 2012
Angus Clarke   +11 more
openalex   +1 more source

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

open access: yesAdvanced Science, EarlyView.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang   +10 more
wiley   +1 more source

Application of RNA-seq for single nucleotide variation identification in a cohort of patients with hypertrophic cardiomyopathy. [PDF]

open access: yesSci Rep
Chumakova A   +7 more
europepmc   +1 more source

SIFTS: Structure Integration with Function, Taxonomy and Sequences resource [PDF]

open access: gold, 2012
Sameer Velankar   +9 more
openalex   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

open access: yesAdvanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang   +5 more
wiley   +1 more source

Sifting through genomes with iterative-sequence clustering produces a large, phylogenetically diverse protein-family resource [PDF]

open access: gold, 2012
Thomas J. Sharpton   +5 more
openalex   +1 more source

Home - About - Disclaimer - Privacy