Results 1 to 10 of about 225,057 (95)

Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

Science Translational Medicine, 2019
Sigma-1 receptor is a critical inhibitor of endoplasmic reticulum–driven inflammation and a potential therapeutic target in septic shock. Sigma-1 receptor subdues systemic inflammation Systemic inflammation can be lethal, as in the case of septic shock ...
Dorian A. Rosen, Scott M. Seki, Anthony Fernández-Castañeda, Rebecca M. Beiter, Jacob D. Eccles, J. Woodfolk, Alban Gaultier   +6 more
semanticscholar   +1 more source

Understanding Delta-Sigma Data Converters

, 2004
Chapter 1: Introduction.Chapter 2: The first-order delta-sigma modulator.Chapter 3: The second-order delta-sigma modulator.Chapter 4: Higher-order delta-sigma modulation.Chapter 5: Bandpass and quadrature delta-sigma modulation.Chapter 6: Implementation ...
S. Pavan, R. Schreier, G. Temes
semanticscholar   +1 more source

Quality Control of Ceramic Wall Products Six Sigma Method with Dmaic Tools and Failure Mode and Effect Analysis (FMEA)

International Journal of Innovative Science and Research Technology
Considering the importance of increasingly rapid industrial development, business people must be aware of the orientation towards product quality. The manufacturing industry has an important role in industrial development.
Muhammad Rizki, Tri Ngudi Wiyatno, Retno Fitri Astuti   +2 more
semanticscholar   +1 more source

An evaluation into the limitations and emerging trends of Six Sigma: an empirical study

The TQM Journal, 2019
Purpose The purpose of this paper is to evaluate the limitations and emerging trends of Six Sigma through an empirical study. Six Sigma is one of the most powerful business process improvement strategies used by numerous World Class corporations for ...
J. Antony, Michael Sony, M. Dempsey, A. Brennan, T. Farrington, E. Cudney   +5 more
semanticscholar   +1 more source

Investigating the green impact of Lean, Six Sigma and Lean Six Sigma: A systematic literature review

, 2017
Purpose The academic literature and research lines exploring the effect of quality improvement methods on environmental performance still remain in early stages.
N. Chugani, Prof Vikas Kumar, J. Garza‐Reyes, Luis Rocha-Lona, A. Upadhyay   +4 more
semanticscholar   +1 more source

Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution

Biomolecules, 2015
Sigma factors are multi-domain subunits of bacterial RNA polymerase (RNAP) that play critical roles in transcription initiation, including the recognition and opening of promoters as well as the initial steps in RNA synthesis.
M. Paget
semanticscholar   +1 more source

Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis

Nature Communications, 2016
Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets, activate bacterial adaptive responses to noxious environments. Here we reconstruct the complete sigma factor regulatory network of the human pathogen Mycobacterium ...
Rinkikumari Chauhan, J. Ravi, Pratik Datta, Tianlong Chen, D. Schnappinger, K. Bassler, G. Balázsi, M. Gennaro   +7 more
semanticscholar   +1 more source

A second criterion for sigma phase formation in high-entropy alloys

, 2016
The presence of the sigma phase in high-entropy alloys significantly affects their mechanical properties. Therefore, control of sigma phase formation is crucial.
M. Tsai, K. Chang, Jian-hong Li, R. Tsai, An-Hung Cheng   +4 more
semanticscholar   +1 more source

Elucidation of Sigma Factor-Associated Networks in Pseudomonas aeruginosa Reveals a Modular Architecture with Limited and Function-Specific Crosstalk

PLoS Pathogens, 2015
Sigma factors are essential global regulators of transcription initiation in bacteria which confer promoter recognition specificity to the RNA polymerase core enzyme.
Sebastian Schulz, Denitsa Eckweiler, Agata Bielecka, Tanja Nicolai, Raimo Franke, Andreas Dötsch, K. Hornischer, Sebastian Bruchmann, Juliane Düvel, S. Häussler   +9 more
semanticscholar   +1 more source

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

PLoS ONE, 2014
Amyloid beta (Abeta) 1–42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation.
N. Izzo, Jinbin Xu, C. Zeng, Molly J. Kirk, Kelsie Mozzoni, Colleen Silky, Courtney Rehak, Raymond Yurko, G. Look, G. Rishton, Hank Safferstein, C. Cruchaga, A. Goate, M. Cahill, O. Arancio, R. Mach, R. Craven, E. Head, H. Levine, T. Spires-Jones, Susan M. Catalano   +20 more
semanticscholar   +1 more source