Results 51 to 60 of about 1,278,506 (289)

Sigma Convergent Analysis of The Production Structure of the Bulgarian Economy

Izvestia Journal of the Union of Scientists - Varna. Economic Sciences Series, 2023
The article examines the structural convergence of production in the Bulgarian economy to the Eurozone using the σ analysis methodology. It first shows the dynamics of the aggregated divergence index and then of the dissimilarity and distance index. These three indices were calculated for each year of the analyzed period, and when interpreting their ...
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

CONVERGENCE OF HEALTH EXPENDITURE IN EU 12 AND V4 STATES

Copernican Journal of Finance & Accounting, 2017
The subject of this paper is an attempt to assess the level of convergence of government health spending in the European Union countries. The ever-increasing level of life expectancy, demographic changes, including the aging of society in many European ...
Piotr Kułyk, Łukasz Augustowski
doaj   +3 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Homogenization of a 2D Tidal Dynamics Equation

Mathematics, 2020
This work deals with the homogenization of two dimensions’ tidal equations. We study the asymptotic behavior of the sequence of the solutions using the sigma-convergence method.
Giuseppe Cardone, Aurelien Fouetio, Jean Louis Woukeng   +2 more
doaj   +1 more source

Interregional Inequality of Population Incomes: Problems of Methodology and Estimation in the Russian Federation [PDF]

SHS Web of Conferences, 2019
Currently, the priority of the Russian Federation socio-economic development is to achieve sustainable economic growth. A significant obstacle to the achievement of this goal is the unevenness and disproportionality in the socio-economic development of ...
Tolmachev M.N., Barashov N.G., Latkov A.V., Markov V.A.   +3 more
doaj   +1 more source

Measuring the Cohesion of Informal Economy in Agriculture in New European Union Member States

Economies, 2022
The present paper evaluates the size and development of the informal economy in agriculture in 10 new EU member states from 2004–2020. A novel agriculture-tailored multiple indicators Multiple Causes model was derived to estimate the size of the informal
Mangirdas Morkunas
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source