Results 31 to 40 of about 29,227 (261)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Bandpass Sigma–Delta Modulation: The Path toward RF-to-Digital Conversion in Software-Defined Radio
Chips, 2023 This paper reviews the state of the art on bandpass ΣΔ modulators (BP-ΣΔMs) intended to digitize radio frequency (RF) signals. A priori, this is the most direct way to implement software-defined radio (SDR) systems since the analog/digital interface is ...
Jose M. de la Rosa
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
IEEE Photonics Journal, 2023 In free space optical (FSO) communication, acquisition, tracking and pointing (ATP) is the key technology to maintain a high-quality FSO link. Specifically, the detection of pointing angle deviation greatly affects the performance of ATP, especially ...
Xueyuan Ao +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
A Hierarchical Modulation Enabled SNR Allocable Delta-Sigma Digital Mobile Fronthaul System
IEEE Photonics Journal, 2022 Internet of everything is being build up rapidly, which causes much higher requirements towards the flexibility of communication resources, especially the adaptivity of the fronthaul to various transmission distances and capacities.
Yang Zou +9 more
doaj +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Analisa Kinerja Sinusoidal PWM Inverter untuk Pengaturan Kecepatan Motor Induksi Tiga Fasa
Teknika, 2016 PWM (pengaturan lebar pulsa) merupakan salah satu teknik yang baik untuk digunakan dalam sistem kendali (control system) saat ini. Pengaturan lebar modulasi dipergunakan di berbagai bidang yang sangat luas, salah satu diantaranya adalah pengaturan ...
Heri Haryanto, Vicky Immanuel
doaj +1 more source
Comparative Study between Duty Cycle Modulation (DCM) and Sigma-Delta (Ʃ∆) Modulation Based on Analog to Digital Conversion [PDF]
Journal of Electrical and Electronics Engineering, 2023 This paper presents a virtual comparative study between the Analog to Digital Conversion (ADC) based Duty Cycle Modulation (DCM) and Sigma-Delta (Ʃ∆) modulation.
OTAM Steve Ulriche, MOFFO Lonla Bertrand
doaj
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source