Results 31 to 40 of about 63,008 (302)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Analysis of Booth Multiplier based Conventional and Short Word Length FIR Filter
Mehran University Research Journal of Engineering and Technology, 2018 The optimized implantation of digital filters has remained one of the challenging tasks, for FPGA (Field- Programmable Gate Array) based system designers, due to the involvement of very complex circuitry for multiplication.
Aneela Pathan +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
W-band radio-over-fiber transmission system with delta-sigma modulation and direct detection
Chinese Optics Letters (COL), 2023 We experimentally built a W-band photonics-aided millimeter-wave radio-over-fiber transmission system and demonstrated the delivery of up to 8192-ary quadrature amplitude modulation (QAM) signal.
Zhou Ju, Jiaxuan Liu, Jianjun Yu
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
IEEE Photonics Journal, 2023 In free space optical (FSO) communication, acquisition, tracking and pointing (ATP) is the key technology to maintain a high-quality FSO link. Specifically, the detection of pointing angle deviation greatly affects the performance of ATP, especially ...
Xueyuan Ao +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
A Hierarchical Modulation Enabled SNR Allocable Delta-Sigma Digital Mobile Fronthaul System
IEEE Photonics Journal, 2022 Internet of everything is being build up rapidly, which causes much higher requirements towards the flexibility of communication resources, especially the adaptivity of the fronthaul to various transmission distances and capacities.
Yang Zou +9 more
doaj +1 more source