Results 61 to 70 of about 130,433 (340)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

DSM-Based Precise Pointing Angle Deviation Measurement Method for Beaconless Free Space Optical Communication

IEEE Photonics Journal, 2023
In free space optical (FSO) communication, acquisition, tracking and pointing (ATP) is the key technology to maintain a high-quality FSO link. Specifically, the detection of pointing angle deviation greatly affects the performance of ATP, especially ...
Xueyuan Ao, Yansheng Zou, Yang Zou, Qirun Fan, Xiaoxiao Dai, Chen Liu, Qi Yang, Deming Liu   +7 more
doaj   +1 more source

An Optimal Family of Exponentially Accurate One-Bit Sigma-Delta Quantization Schemes [PDF]

, 2010
Sigma-Delta modulation is a popular method for analog-to-digital conversion of bandlimited signals that employs coarse quantization coupled with oversampling.
Deift, Percy, Güntürk, C. Sinan, Krahmer, Felix   +2 more
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Analisa Kinerja Sinusoidal PWM Inverter untuk Pengaturan Kecepatan Motor Induksi Tiga Fasa

Teknika, 2016
PWM (pengaturan lebar pulsa) merupakan salah satu teknik yang baik untuk digunakan dalam sistem kendali (control system) saat ini. Pengaturan lebar modulasi dipergunakan di berbagai bidang yang sangat luas, salah satu diantaranya adalah pengaturan ...
Heri Haryanto, Vicky Immanuel
doaj   +1 more source

Comparative Study between Duty Cycle Modulation (DCM) and Sigma-Delta (Ʃ∆) Modulation Based on Analog to Digital Conversion [PDF]

Journal of Electrical and Electronics Engineering, 2023
This paper presents a virtual comparative study between the Analog to Digital Conversion (ADC) based Duty Cycle Modulation (DCM) and Sigma-Delta (Ʃ∆) modulation.
OTAM Steve Ulriche, MOFFO Lonla Bertrand
doaj  

HTS pulse-stretcher and second order modulator: design and first results [PDF]

, 2005
One of the remaining challenges in the application of superconducting electronics is the interfacing between superconducting and semiconducting environments. The voltage and speed mismatch between RSFQ pulses and semiconducting read-out electronics makes
Brinkman, Alexander, Oomen, I., Ortlepp, T., Ortlepp, Th., Rogalla, Horst, Roussy, Agnes M.M., Shunmugavel, K., Sujiono, E.H., Sujiono, E.H.   +8 more
core   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Optimum quantization of a class of non-bandlimited signals [PDF]

, 1996
We consider the quantization of a special class of non bandlimited signals, namely the class of discrete time signals that can be recovered from their decimated version.
Tuqan, Jamal, Vaidyanathan, P.P.
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source