Results 91 to 100 of about 1,815,787 (311)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

A recurrent sigma pi sigma neural network

open access: yesScientific Reports
In this paper, a novel recurrent sigma‒sigma neural network (RSPSNN) that contains the same advantages as the higher-order and recurrent neural networks is proposed. The batch gradient algorithm is used to train the RSPSNN to search for the optimal weights based on the minimal mean squared error (MSE).
Fei Deng   +4 more
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

On the sigma sigma term

open access: yes, 2016
We give some estimates for the light-quark mass dependence of the pole position of the sigma ($f_{0}(500)$) resonance in the complex energy plane, with the help of a chiral Lagrangian for the resonance field and some input from hadronic models constrained by Chiral Perturbation Theory and elastic unitarity.
openaire   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Photonic neuromorphic architecture for tens-of-task lifelong learning

open access: yesLight: Science & Applications
Scalable, high-capacity, and low-power computing architecture is the primary assurance for increasingly manifold and large-scale machine learning tasks.
Yuan Cheng   +6 more
doaj   +1 more source

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